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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-10-1
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pubmed:abstractText |
The pathophysiology of neuroleptic malignant syndrome is mainly explained by a central hypodopaminergic state. The familial occurrence of neuroleptic malignant syndrome suggests the involvement of a genetic mechanism in the predisposition to the syndrome. Therefore, the authors examined the association between the TaqI A polymorphism of the dopamine D(2) receptor gene (DRD(2)), which alters DRD(2) density and function, and the development of neuroleptic malignant syndrome.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-953X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1714-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11579007-Adult,
pubmed-meshheading:11579007-Antipsychotic Agents,
pubmed-meshheading:11579007-Depressive Disorder,
pubmed-meshheading:11579007-Female,
pubmed-meshheading:11579007-Gene Frequency,
pubmed-meshheading:11579007-Genetic Predisposition to Disease,
pubmed-meshheading:11579007-Genotype,
pubmed-meshheading:11579007-Humans,
pubmed-meshheading:11579007-Male,
pubmed-meshheading:11579007-Neuroleptic Malignant Syndrome,
pubmed-meshheading:11579007-Polymerase Chain Reaction,
pubmed-meshheading:11579007-Polymorphism, Genetic,
pubmed-meshheading:11579007-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:11579007-Receptors, Dopamine D2,
pubmed-meshheading:11579007-Schizophrenia,
pubmed-meshheading:11579007-Taq Polymerase
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pubmed:year |
2001
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pubmed:articleTitle |
Association of the TaqI A polymorphism of the dopamine D(2) receptor gene with predisposition to neuroleptic malignant syndrome.
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pubmed:affiliation |
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan.
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pubmed:publicationType |
Journal Article
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