Source:http://linkedlifedata.com/resource/pubmed/id/11578841
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-10-1
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| pubmed:abstractText |
Cerebral arterial vasospasm is a frequent complication after aneurysmal subarachnoid hemorrhage (SAH). Immunological activation may affect the development of vasospasm. This study measured the cytokines released from lipopolysaccharide-stimulated monocytes of SAH patients. We measured cerebral artery diameters before and after surgery for SAH. The activation index of interleukin-1 beta (IL-1 beta), but not tumor necrosis factor-alpha (TNF-alpha), was higher in patients with symptomatic vasospasm (5.6+/-1.7; n=11) than in patients without (1.8+/-0.4; n=11) (P=0.039). Furthermore, the IL-1 beta activation index was correlated with the degree of the postoperative angiographic vasospasm (correlation coefficient=-0.66, P=0.007). Individual variation in systemic immune activation, measured by monocyte-derived IL-1 beta expression levels after stimulation, may be associated with the development of vasospasm after aneurysmal SAH.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
0304-3940
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
12
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| pubmed:volume |
312
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
41-4
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11578841-Adult,
pubmed-meshheading:11578841-Aged,
pubmed-meshheading:11578841-Aged, 80 and over,
pubmed-meshheading:11578841-Cerebral Angiography,
pubmed-meshheading:11578841-Cerebral Arteries,
pubmed-meshheading:11578841-Female,
pubmed-meshheading:11578841-Glasgow Outcome Scale,
pubmed-meshheading:11578841-Humans,
pubmed-meshheading:11578841-Immune System,
pubmed-meshheading:11578841-Interleukin-1,
pubmed-meshheading:11578841-Lipopolysaccharides,
pubmed-meshheading:11578841-Male,
pubmed-meshheading:11578841-Middle Aged,
pubmed-meshheading:11578841-Monocytes,
pubmed-meshheading:11578841-RNA, Messenger,
pubmed-meshheading:11578841-Subarachnoid Hemorrhage,
pubmed-meshheading:11578841-Tumor Necrosis Factor-alpha,
pubmed-meshheading:11578841-Vasospasm, Intracranial
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Expression of interleukin-1 beta in lipopolysaccharide stimulated monocytes derived from patients with aneurysmal subarachnoid hemorrhage is correlated with cerebral vasospasm.
|
| pubmed:affiliation |
Department of Neurosurgery, Samsung Medical Center and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, Seoul 135-710, South Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|