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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-10-1
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pubmed:abstractText |
Stimulation of central 5-HT(1A) receptors produces bradycardia and diminishes blood pressure in conscious or anesthetized rats. Our objective was to investigate the effects on blood pressure and heart rate of the partial 5-HT(1A) receptor agonist and selective alpha1D-adrenoceptor antagonist BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-8-azaspiro [4.5] decane-7,9 dione hydrochloride) compared to the full 5-HT(1A) receptor agonist 8-OH-DPAT (8-hydroxy-dipropylamino tetralin) in adult anesthetized rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/BMY 7378,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/WAY 100635
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pubmed:status |
MEDLINE
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pubmed:issn |
0188-4409
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
389-93
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11578753-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:11578753-Adrenergic alpha-1 Receptor Antagonists,
pubmed-meshheading:11578753-Adrenergic alpha-Antagonists,
pubmed-meshheading:11578753-Animals,
pubmed-meshheading:11578753-Blood Pressure,
pubmed-meshheading:11578753-Drug Interactions,
pubmed-meshheading:11578753-Heart Rate,
pubmed-meshheading:11578753-Male,
pubmed-meshheading:11578753-Piperazines,
pubmed-meshheading:11578753-Pyridines,
pubmed-meshheading:11578753-Rats,
pubmed-meshheading:11578753-Rats, Wistar,
pubmed-meshheading:11578753-Receptors, Serotonin,
pubmed-meshheading:11578753-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:11578753-Serotonin Receptor Agonists
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pubmed:articleTitle |
The hypotensive effect of BMY 7378 is antagonized by a silent 5-HT(1A) receptor antagonist: comparison with 8-hydroxy-dipropylamino tetralin.
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pubmed:affiliation |
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Instituto Politécnico Nacional (IPN), Mexico City, Mexico. raffaeld@prodigy.net.mx
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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