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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-10-1
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pubmed:abstractText |
The distribution of 5-HT(1B) and 5-HT(1D) receptors in the human post mortem brain was examined using whole hemisphere autoradiography and the radioligand [(3)H]GR 125743. [(3)H]GR 125743 binding was highest in the substantia nigra and the globus pallidus. Lower levels were detected in the striatum, with the highest densities in the ventromedial parts. In the amygdala, the hippocampus, the septal region and the hypothalamus, lower [(3)H]GR 125743 binding was observed, reflecting low densities of 5-HT(1B/1D) receptors. In the cerebral cortex, binding was similar in most regions, although restricted parts of the medial occipital cortex were markedly more densely labeled. Binding densities were very low in the cerebellar cortex and in the thalamus. Two methods were used to distinguish between the two receptor subtypes, the first using ketanserin to block 5-HT(1D) receptors and the second using SB 224289 to inhibit 5-HT(1B) receptor binding. The autoradiograms indicated that in the human brain, the 5-HT(1B) receptor is much more abundant than the 5-HT(1D) receptor, which seemed to occur only in low amounts mainly in the ventral pallidum. Although [(3)H]GR 125743 is a suitable radioligand to examine the distribution of 5-HT(1B) receptors in the human brain in vitro, the selectivities of ketanserin and SB 224289 are not sufficiently high to give definite evidence for the occurrence of the 5-HT(1D) receptor in the human brain.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/HTR1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/N-(4-methoxy-3-(4-methylpiperazin-1-...,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidones,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1B,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1D,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/SB 22489G,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Spiro Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
915
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47-57
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11578619-Basal Ganglia,
pubmed-meshheading:11578619-Benzamides,
pubmed-meshheading:11578619-Binding Sites,
pubmed-meshheading:11578619-Brain,
pubmed-meshheading:11578619-Female,
pubmed-meshheading:11578619-Hippocampus,
pubmed-meshheading:11578619-Humans,
pubmed-meshheading:11578619-Male,
pubmed-meshheading:11578619-Middle Aged,
pubmed-meshheading:11578619-Neocortex,
pubmed-meshheading:11578619-Neurons,
pubmed-meshheading:11578619-Piperidones,
pubmed-meshheading:11578619-Pyridines,
pubmed-meshheading:11578619-Radioligand Assay,
pubmed-meshheading:11578619-Receptor, Serotonin, 5-HT1B,
pubmed-meshheading:11578619-Receptor, Serotonin, 5-HT1D,
pubmed-meshheading:11578619-Receptors, Serotonin,
pubmed-meshheading:11578619-Serotonin,
pubmed-meshheading:11578619-Serotonin Antagonists,
pubmed-meshheading:11578619-Spiro Compounds,
pubmed-meshheading:11578619-Tritium
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pubmed:year |
2001
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pubmed:articleTitle |
Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743.
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pubmed:affiliation |
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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