Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-10-1
pubmed:abstractText
Nicotine is a neuroteratogen that targets synaptic function during critical developmental stages and recent studies indicate that CNS vulnerability extends into adolescence, the time that smoking typically commences. We administered nicotine to pregnant or adolescent rats via continuous minipump infusions, using dose rates that replicate the plasma nicotine levels found in smokers. Fetal nicotine exposure (gestational days 4-21) decreased the cerebrocortical binding of paroxetine (PXT), a marker for the serotonin (5HT) transporter, likely indicative of a decrease in nerve terminals in that region; the effect lasted into adulthood. There was a corresponding increase in PXT binding in the midbrain/brainstem, the region containing the 5HT cell bodies that project to the cerebral cortex, a pattern typical of reactive sprouting in response to nerve terminal damage. After adolescent nicotine treatment (postnatal days 30-47), PXT binding was reduced in the hippocampus and striatum instead of the cerebral cortex, again accompanied by increased binding in the midbrain and brainstem; the patterns of effects within each region were gender-selective, although both males and females displayed abnormalities. Superimposed on this overall effect, there were transient increases in PXT binding, likely due to acute stimulant effects of nicotine. We also assessed 5HT presynaptic activity (5HIAA/5HT ratio). Withdrawal from adolescent nicotine treatment led to suppression of activity in the cerebral cortex and activation in the midbrain. These results indicate that both fetal and adolescent nicotine exposure elicit apparent damage to 5HT projections with reactive increases in regions containing 5HT cell bodies. Long-term changes in 5HT innervation and/or synaptic activity may play a role in the subsequent development of depression in the offspring of women who smoke during pregnancy or in adolescent smokers.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
914
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
166-78
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11578609-Aging, pubmed-meshheading:11578609-Animals, pubmed-meshheading:11578609-Binding Sites, pubmed-meshheading:11578609-Brain, pubmed-meshheading:11578609-Carrier Proteins, pubmed-meshheading:11578609-Embryo, Mammalian, pubmed-meshheading:11578609-Female, pubmed-meshheading:11578609-Hydroxyindoleacetic Acid, pubmed-meshheading:11578609-Male, pubmed-meshheading:11578609-Membrane Glycoproteins, pubmed-meshheading:11578609-Membrane Transport Proteins, pubmed-meshheading:11578609-Nerve Degeneration, pubmed-meshheading:11578609-Nerve Tissue Proteins, pubmed-meshheading:11578609-Nicotine, pubmed-meshheading:11578609-Paroxetine, pubmed-meshheading:11578609-Pregnancy, pubmed-meshheading:11578609-Prenatal Exposure Delayed Effects, pubmed-meshheading:11578609-Presynaptic Terminals, pubmed-meshheading:11578609-Radioligand Assay, pubmed-meshheading:11578609-Rats, pubmed-meshheading:11578609-Rats, Sprague-Dawley, pubmed-meshheading:11578609-Serotonin, pubmed-meshheading:11578609-Serotonin Plasma Membrane Transport Proteins, pubmed-meshheading:11578609-Sex Characteristics, pubmed-meshheading:11578609-Synaptic Transmission, pubmed-meshheading:11578609-Tobacco Use Disorder
pubmed:year
2001
pubmed:articleTitle
Fetal and adolescent nicotine administration: effects on CNS serotonergic systems.
pubmed:affiliation
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't