Linked Life Data

11576849

Source:http://linkedlifedata.com/resource/pubmed/id/11576849

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2001-9-28
pubmed:abstractText
The effect of human methaemoglobin (metHb), possibly derived from extravasated red blood cells in tumours showing neovascularisation and haemorrhage, on the growth of transformed human epithelial cells was investigated. MetHb stimulated the growth of immortalised epithelial cells or transformed cells at precrisis stage (cells have bypassed M1, but not M2, the two mortality checkpoints). The stimulatory effect was due to the release of haemin from metHb that was isolated by a Sephadex column and identified by its characteristic light absorption spectrum. Although all the degradation products of haemin are currently known to be physiologically significant, only ferric iron derived from metHb or haemin could stimulate cell growth. High concentrations of metHb or haemin inhibited cell growth possibly due to the generation of high concentrations of bilirubin. However, bilirubin formed in the cells of human body is known to be transported to the liver for further processing and excretion. Haemoglobin oxidised to where tumours show neovascularisation and haemorrhage likely contributes significantly to the increased proliferation of cancerous cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0959-8049
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1921-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Methaemoglobin enhances the proliferation of transformed human epithelial cells: a possible outcome of neovascularisation and haemorrhage in tumours?
pubmed:affiliation
Institute of Biochemistry, College of Medicine, National Taiwan University, 100, Taipei, Taiwan. wwn@ha.mc.ntu.edu.tw
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't