|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2001-9-28
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|
pubmed:abstractText |
Tachyphylaxis to sciatic nerve blockade in rats correlates with hyperalgesia. Spinal inhibition of nitric oxide synthase with N(G)nitro-L-arginine methyl ester (L-NAME) has been shown to prevent hyperalgesia. Given systemically, L-NAME also prevents tachyphylaxis. The action of L-NAME in preventing tachyphylaxis therefore may be mediated at spinal sites. We compared systemic versus intrathecal potency of L-NAME in modulating tachyphylaxis to sciatic nerve block.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0001-5172
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
45
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
945-53
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:11576044-Anesthetics, Local,
pubmed-meshheading:11576044-Animals,
pubmed-meshheading:11576044-Arginine,
pubmed-meshheading:11576044-Male,
pubmed-meshheading:11576044-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:11576044-Nerve Block,
pubmed-meshheading:11576044-Nitric Oxide,
pubmed-meshheading:11576044-Procaine,
pubmed-meshheading:11576044-Rats,
pubmed-meshheading:11576044-Rats, Sprague-Dawley,
pubmed-meshheading:11576044-Spinal Cord,
pubmed-meshheading:11576044-Tachyphylaxis
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
Evidence that spinal segmental nitric oxide mediates tachyphylaxis to peripheral local anesthetic nerve block.
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|
pubmed:affiliation |
Department of Anesthesia, Children's Hospital, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
