11575946

Source:http://linkedlifedata.com/resource/pubmed/id/11575946

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006349, umls-concept:C0013227, umls-concept:C0021469, umls-concept:C0152035, umls-concept:C0204727, umls-concept:C0205409, umls-concept:C0443324, umls-concept:C0678594, umls-concept:C1516170, umls-concept:C1548559
pubmed:issue	9
pubmed:dateCreated	2001-9-28
pubmed:abstractText	Five new bufadienolides, 3beta-formyloxyresibufogenin (1), 19-oxobufalin (2), 19-oxodesacetylcinobufagin (3), 6alpha-hydroxycinobufagin (4), and 1beta-hydroxybufalin (5), have been isolated together with the previously known bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the KB and HL-60 cancer cell lines. In addition, bufadienolide 1 was found active against the MH-60 cancer cell line.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA-44344-01A1-12
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/11575946
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7906882
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Bufanolides
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0163-3864
pubmed:author	pubmed-author:KamanoYY, pubmed-author:NogawaTT, pubmed-author:PettitG RGR, pubmed-author:YamashitaAA
pubmed:issnType	Print
pubmed:volume	64
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1148-52
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:11575946-Animals, pubmed-meshheading:11575946-Antineoplastic Agents, pubmed-meshheading:11575946-Bufanolides, pubmed-meshheading:11575946-Bufonidae, pubmed-meshheading:11575946-Chromatography, High Pressure Liquid, pubmed-meshheading:11575946-Chromatography, Thin Layer, pubmed-meshheading:11575946-HL-60 Cells, pubmed-meshheading:11575946-Humans, pubmed-meshheading:11575946-KB Cells, pubmed-meshheading:11575946-Leukemia, Myeloid, pubmed-meshheading:11575946-Magnetic Resonance Spectroscopy, pubmed-meshheading:11575946-Medicine, Chinese Traditional, pubmed-meshheading:11575946-Mice, pubmed-meshheading:11575946-Molecular Conformation, pubmed-meshheading:11575946-Molecular Structure, pubmed-meshheading:11575946-Nasopharyngeal Neoplasms, pubmed-meshheading:11575946-Skin, pubmed-meshheading:11575946-Spectrophotometry, Infrared, pubmed-meshheading:11575946-Spectrophotometry, Ultraviolet, pubmed-meshheading:11575946-Tumor Cells, Cultured
pubmed:year	2001
pubmed:articleTitle	Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.
pubmed:affiliation	Faculty of Science, Kanagawa University, 2946 Tsuchiya, Hiratsuka, Kanagawa 259-1293, Japan.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't