|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006675,
umls-concept:C0012984,
umls-concept:C0017337,
umls-concept:C0024591,
umls-concept:C0026882,
umls-concept:C0030685,
umls-concept:C0242692,
umls-concept:C0391871,
umls-concept:C0439799,
umls-concept:C0443147,
umls-concept:C0679058,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1314792,
umls-concept:C1419778,
umls-concept:C1547699,
umls-concept:C1963578,
umls-concept:C2700640
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2001-9-28
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|
pubmed:abstractText |
Malignant hyperthermia (MH) is an inherited disorder of skeletal muscle characterized by hypercarbia, rhabdomyolysis, generalized skeletal muscle contracture, cardiac dysrhythmia, and renal failure, that develops on exposure to succinylcholine or volatile anesthetic agents. All swine and up to 50% of human MH events are thought to be associated with mutations in the calcium release channel of the sarcoplasmic reticulum, also known as the ryanodine receptor (RYR1). Events resembling MH have been reported in other species, but none have undergone genetic investigation to date.
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pubmed:grant |
|
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pubmed:language |
eng
|
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pubmed:journal |
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|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0003-3022
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:volume |
95
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
716-25
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11575546-Amino Acid Sequence,
pubmed-meshheading:11575546-Animals,
pubmed-meshheading:11575546-Dog Diseases,
pubmed-meshheading:11575546-Dogs,
pubmed-meshheading:11575546-Female,
pubmed-meshheading:11575546-Genotype,
pubmed-meshheading:11575546-Halothane,
pubmed-meshheading:11575546-Malignant Hyperthermia,
pubmed-meshheading:11575546-Molecular Sequence Data,
pubmed-meshheading:11575546-Muscle Contraction,
pubmed-meshheading:11575546-Mutation,
pubmed-meshheading:11575546-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:11575546-Succinylcholine
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
Autosomal dominant canine malignant hyperthermia is caused by a mutation in the gene encoding the skeletal muscle calcium release channel (RYR1).
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|
pubmed:affiliation |
Department of Veterinary Pathobiology, University of Minnesota, Minneapolis, USA.
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|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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