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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2001-9-27
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pubmed:abstractText |
Contribution of Vgamma9/Vdelta2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vgamma9/Vdelta2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vgamma9/Vdelta2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vgamma9/Vdelta2 T lymphocytes, play a major role, which indicates that Vgamma9/Vdelta2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
184
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1082-5
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pubmed:dateRevised |
2010-9-1
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pubmed:meshHeading |
pubmed-meshheading:11574927-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:11574927-Cytotoxicity, Immunologic,
pubmed-meshheading:11574927-Humans,
pubmed-meshheading:11574927-Macrophages,
pubmed-meshheading:11574927-Mycobacterium tuberculosis,
pubmed-meshheading:11574927-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:11574927-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:11574927-T-Lymphocytes,
pubmed-meshheading:11574927-Tuberculosis
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pubmed:year |
2001
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pubmed:articleTitle |
Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes.
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pubmed:affiliation |
Dipartimento di Biopatologia, Università di Palermo, Palermo, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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