Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-9-27
pubmed:abstractText
The FHIT gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumor suppressor gene involved in multiple tumors, including esophageal carcinoma. We analyzed Fhit expression using an immunohistochemical method in invasive carcinoma, carcinoma in situ (CIS) and dysplasia, in paraffin sections of 75 esophageal squamous cell carcinomas (ESCs) to further elucidate the role of Fhit protein in esophageal carcinogenesis. In addition, we also examined whether Fhit expression correlated with p53 expression and apoptosis. Compared to adjacent normal mucosa, significant loss or reduction of Fhit expression was noted in 67 of 75 (89.3%) invasive ESCs, in 13 of 19 (68.4%) CIS lesions, and in 10 of 23 (43.5%) dysplastic lesions. There was a progressive loss or reduction of Fhit expression with progressive increases in the severity of histopathological changes (p < 0.001). However, there was no association between Fhit expression and clinicopathological findings, including tumor stage, lymph node metastasis, or overall survival. Moreover, Fhit expression was not significantly associated with p53 expression and apoptosis. These results indicate that abnormal Fhit expression is a common event in the early stage of ESC development and may occur independently of p53 expression and apoptosis mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0030-2414
pubmed:author
pubmed:copyrightInfo
Copyright 2001 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11574776-Acid Anhydride Hydrolases, pubmed-meshheading:11574776-Adult, pubmed-meshheading:11574776-Aged, pubmed-meshheading:11574776-Aged, 80 and over, pubmed-meshheading:11574776-Apoptosis, pubmed-meshheading:11574776-Carcinoma, Squamous Cell, pubmed-meshheading:11574776-Carcinoma in Situ, pubmed-meshheading:11574776-Cell Transformation, Neoplastic, pubmed-meshheading:11574776-Disease Progression, pubmed-meshheading:11574776-Enzyme Induction, pubmed-meshheading:11574776-Epithelial Cells, pubmed-meshheading:11574776-Esophageal Diseases, pubmed-meshheading:11574776-Esophageal Neoplasms, pubmed-meshheading:11574776-Esophagus, pubmed-meshheading:11574776-Female, pubmed-meshheading:11574776-Gene Expression Regulation, Neoplastic, pubmed-meshheading:11574776-Genes, p53, pubmed-meshheading:11574776-Humans, pubmed-meshheading:11574776-Lymphatic Metastasis, pubmed-meshheading:11574776-Male, pubmed-meshheading:11574776-Middle Aged, pubmed-meshheading:11574776-Mucous Membrane, pubmed-meshheading:11574776-Neoplasm Invasiveness, pubmed-meshheading:11574776-Neoplasm Proteins, pubmed-meshheading:11574776-Precancerous Conditions, pubmed-meshheading:11574776-Retrospective Studies, pubmed-meshheading:11574776-Tumor Suppressor Protein p53
pubmed:year
2001
pubmed:articleTitle
Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis.
pubmed:affiliation
Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't