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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-9-27
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pubmed:abstractText |
Azimilide blocks the slow (I(Ks)) and fast (I(Kr)) components of the delayed rectifier potassium channel. It also has blocking effects on sodium (I(Na)) and calcium currents (I(CaL)). Its effects on reentrant circuits in infarct border zones causing ventricular tachyarrhythmias are unknown.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1045-3873
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1025-33
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11573692-Animals,
pubmed-meshheading:11573692-Anti-Arrhythmia Agents,
pubmed-meshheading:11573692-Dogs,
pubmed-meshheading:11573692-Drug Evaluation, Preclinical,
pubmed-meshheading:11573692-Electrocardiography,
pubmed-meshheading:11573692-Imidazoles,
pubmed-meshheading:11573692-Imidazolidines,
pubmed-meshheading:11573692-Male,
pubmed-meshheading:11573692-Models, Animal,
pubmed-meshheading:11573692-Myocardial Infarction,
pubmed-meshheading:11573692-Piperazines,
pubmed-meshheading:11573692-Tachycardia, Ventricular,
pubmed-meshheading:11573692-Ventricular Fibrillation
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pubmed:year |
2001
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pubmed:articleTitle |
Effects of azimilide, a new class III antiarrhythmic drug, on reentrant circuits causing ventricular tachycardia and fibrillation in a canine model of myocardial infarction.
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pubmed:affiliation |
Department of Pharmacology, Center of Molecular Therapeutics, College of Physicians & Surgeons of Columbia University, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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