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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12 Suppl 1
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pubmed:dateCreated |
2001-9-24
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pubmed:abstractText |
Interleukin-1 (IL-1) plays a role in mediating acute inflammation during ischemia-reperfusion (I/R) injury in the heart, which leads to both necrosis and apoptosis of cardiomyocytes. IL-1 receptor antagonist (IL-1ra) is known to inhibit the effects of IL-1alpha and IL-1beta, resulting in attenuated inflammatory injury, and to protect cells from IL-1beta-induced apoptosis in vitro. We hypothesized that IL-1ra overexpression would provide cardioprotection by reducing inflammation-mediated myocardial damage including apoptosis after I/R injury in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
I308-I3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11568074-Animals,
pubmed-meshheading:11568074-Apoptosis,
pubmed-meshheading:11568074-Disease Models, Animal,
pubmed-meshheading:11568074-Gene Expression,
pubmed-meshheading:11568074-Heart Transplantation,
pubmed-meshheading:11568074-Humans,
pubmed-meshheading:11568074-Inflammation,
pubmed-meshheading:11568074-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:11568074-Liposomes,
pubmed-meshheading:11568074-Male,
pubmed-meshheading:11568074-Myocardial Infarction,
pubmed-meshheading:11568074-Myocardium,
pubmed-meshheading:11568074-Peroxidase,
pubmed-meshheading:11568074-Rats,
pubmed-meshheading:11568074-Rats, Inbred Lew,
pubmed-meshheading:11568074-Reperfusion Injury,
pubmed-meshheading:11568074-Respirovirus,
pubmed-meshheading:11568074-Sialoglycoproteins,
pubmed-meshheading:11568074-Transfection
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pubmed:year |
2001
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pubmed:articleTitle |
Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis.
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pubmed:affiliation |
Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College School of Medicine at the Heart Science Centre, Harefield Hospital, Middlesex, UK.
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pubmed:publicationType |
Journal Article,
In Vitro
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