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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5542
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pubmed:dateCreated |
2001-10-19
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pubmed:abstractText |
The localization of gammadelta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gammadelta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis. After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex-related molecules structurally resembling human MICA. Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells. In vitro, skin-associated NKG2d+ gammadelta cells killed skin carcinoma cells by a mechanism that was sensitive to blocking NKG2d engagement. Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/KLRK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Klrk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/MHC class I-related chain A,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Minor Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Raet1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/minor H antigen H60
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
294
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
605-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11567106-Amino Acid Sequence,
pubmed-meshheading:11567106-Animals,
pubmed-meshheading:11567106-Carcinogens,
pubmed-meshheading:11567106-Cell Line,
pubmed-meshheading:11567106-Cytotoxicity, Immunologic,
pubmed-meshheading:11567106-Dimerization,
pubmed-meshheading:11567106-Epidermis,
pubmed-meshheading:11567106-Epithelial Cells,
pubmed-meshheading:11567106-Histocompatibility Antigens Class I,
pubmed-meshheading:11567106-Humans,
pubmed-meshheading:11567106-Immunologic Surveillance,
pubmed-meshheading:11567106-Ligands,
pubmed-meshheading:11567106-Membrane Proteins,
pubmed-meshheading:11567106-Mice,
pubmed-meshheading:11567106-Mice, Inbred C57BL,
pubmed-meshheading:11567106-Minor Histocompatibility Antigens,
pubmed-meshheading:11567106-Molecular Sequence Data,
pubmed-meshheading:11567106-NK Cell Lectin-Like Receptor Subfamily K,
pubmed-meshheading:11567106-Protein Conformation,
pubmed-meshheading:11567106-Protein Folding,
pubmed-meshheading:11567106-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:11567106-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:11567106-Receptors, Immunologic,
pubmed-meshheading:11567106-Receptors, Natural Killer Cell,
pubmed-meshheading:11567106-Recombinant Fusion Proteins,
pubmed-meshheading:11567106-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11567106-Skin Neoplasms,
pubmed-meshheading:11567106-T-Lymphocyte Subsets
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pubmed:year |
2001
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pubmed:articleTitle |
Regulation of cutaneous malignancy by gammadelta T cells.
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pubmed:affiliation |
Department of Dermatology and Yale Skin Diseases Research Core Center, King's College, London SE1 9RT, UK.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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