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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2001-9-21
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pubmed:abstractText |
Contactin (also known as F3, F11) is a surface glycoprotein that has significant homology with the beta2 subunit of voltage-gated Na(+) channels. Contactin and Na(+) channels can be reciprocally coimmunoprecipitated from brain homogenates, indicating association within a complex. Cells cotransfected with Na(+) channel Na(v)1.2alpha and beta1 subunits and contactin have threefold to fourfold higher peak Na(+) currents than cells with Na(v)1.2alpha alone, Na(v)1.2/beta1, Na(v)1.2/contactin, or Na(v)1.2/beta1/beta2. These cells also have a correspondingly higher saxitoxin binding, suggesting an increased Na(+) channel surface membrane density. Coimmunoprecipitation of different subunits from cell lines shows that contactin interacts specifically with the beta1 subunit. In the PNS, immunocytochemical studies show a transient colocalization of contactin and Na(+) channels at new nodes of Ranvier forming during remyelination. In the CNS, there is a particularly high level of colocalization of Na(+) channels and contactin at nodes both during development and in the adult. Contactin may thus significantly influence the functional expression and distribution of Na(+) channels in neurons.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules, Neuronal,
http://linkedlifedata.com/resource/pubmed/chemical/Contactins,
http://linkedlifedata.com/resource/pubmed/chemical/Lysophosphatidylcholines,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/Saxitoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/sodium channel, voltage-gated...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1529-2401
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pubmed:author |
pubmed-author:BerglundE OEO,
pubmed-author:IsomL LLL,
pubmed-author:Kazarinova-NoyesKK,
pubmed-author:LevinsonS RSR,
pubmed-author:MalhotraJ DJD,
pubmed-author:MatteiL NLN,
pubmed-author:McEwenD PDP,
pubmed-author:RanschtBB,
pubmed-author:SchachnerMM,
pubmed-author:ShragerPP,
pubmed-author:XiaoZ CZC
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7517-25
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:11567041-Animals,
pubmed-meshheading:11567041-Axons,
pubmed-meshheading:11567041-Binding, Competitive,
pubmed-meshheading:11567041-Brain Chemistry,
pubmed-meshheading:11567041-CHO Cells,
pubmed-meshheading:11567041-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:11567041-Cell Line,
pubmed-meshheading:11567041-Cell Membrane,
pubmed-meshheading:11567041-Contactins,
pubmed-meshheading:11567041-Cricetinae,
pubmed-meshheading:11567041-Demyelinating Diseases,
pubmed-meshheading:11567041-Female,
pubmed-meshheading:11567041-Gene Expression,
pubmed-meshheading:11567041-Lysophosphatidylcholines,
pubmed-meshheading:11567041-Nerve Tissue Proteins,
pubmed-meshheading:11567041-Patch-Clamp Techniques,
pubmed-meshheading:11567041-Precipitin Tests,
pubmed-meshheading:11567041-Protein Subunits,
pubmed-meshheading:11567041-Ranvier's Nodes,
pubmed-meshheading:11567041-Rats,
pubmed-meshheading:11567041-Saxitoxin,
pubmed-meshheading:11567041-Sciatic Nerve,
pubmed-meshheading:11567041-Sodium,
pubmed-meshheading:11567041-Sodium Channel Blockers,
pubmed-meshheading:11567041-Sodium Channels,
pubmed-meshheading:11567041-Tetrodotoxin,
pubmed-meshheading:11567041-Transfection
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pubmed:year |
2001
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pubmed:articleTitle |
Contactin associates with Na+ channels and increases their functional expression.
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pubmed:affiliation |
Departments of Neurobiology/Anatomy and Biochemistry/Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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