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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-9-21
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pubmed:databankReference |
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pubmed:abstractText |
In Aspergillus nidulans, the transcription activator AlcR mediates specific induction of a number of the genes of the alc cluster. This cluster includes genes involved in the oxidation of ethanol and other alcohols to acetate. The pattern of binding and of transactivation of AlcR is unique within the Zn(2)Cys(6) family. The structural bases for these specificities have not been analyzed at the atomic level until now.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
827-36
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11566132-Amino Acid Sequence,
pubmed-meshheading:11566132-Aspergillus nidulans,
pubmed-meshheading:11566132-Cysteine,
pubmed-meshheading:11566132-DNA,
pubmed-meshheading:11566132-DNA-Binding Proteins,
pubmed-meshheading:11566132-Fungal Proteins,
pubmed-meshheading:11566132-Gene Expression Regulation, Fungal,
pubmed-meshheading:11566132-Models, Molecular,
pubmed-meshheading:11566132-Molecular Sequence Data,
pubmed-meshheading:11566132-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:11566132-Nucleic Acid Conformation,
pubmed-meshheading:11566132-Protein Binding,
pubmed-meshheading:11566132-Protein Conformation,
pubmed-meshheading:11566132-Solutions,
pubmed-meshheading:11566132-Structure-Activity Relationship,
pubmed-meshheading:11566132-Substrate Specificity,
pubmed-meshheading:11566132-Thermodynamics,
pubmed-meshheading:11566132-Zinc
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pubmed:year |
2001
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pubmed:articleTitle |
The solution structure of an AlcR-DNA complex sheds light onto the unique tight and monomeric DNA binding of a Zn(2)Cys(6) protein.
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pubmed:affiliation |
Laboratoire de Résonance Magnétique Nucléaire, ICSN-CNRS, 1 Avenue de la Terrasse, Gif-sur-Yvette F-91190, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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