| pubmed-article:11564799 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11564799 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11564799 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:11564799 | lifeskim:mentions | umls-concept:C1457869 | lld:lifeskim |
| pubmed-article:11564799 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:11564799 | lifeskim:mentions | umls-concept:C0870432 | lld:lifeskim |
| pubmed-article:11564799 | lifeskim:mentions | umls-concept:C1705417 | lld:lifeskim |
| pubmed-article:11564799 | lifeskim:mentions | umls-concept:C1555465 | lld:lifeskim |
| pubmed-article:11564799 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:11564799 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11564799 | pubmed:dateCreated | 2001-9-20 | lld:pubmed |
| pubmed-article:11564799 | pubmed:abstractText | Thymic expression of self-Ags results in the deletion of high-avidity self-specific T cells, but, at least for certain Ags, a residual population of self-specific T cells with low-affinity TCRs remains after negative selection. Such self-specific T cells are thought to play a role in the induction of T cell-mediated autoimmunity, but may also be used for the induction of antitumor immunity against self-Ags. In this study, we examine the functional competence of a polyclonal population of self-specific CD8+ T cells. We show that low-affinity interactions between TCR and peptide are associated with selective loss of critical T cell functions. Triggering of low levels of IFN-gamma production and cytolytic activity through low-affinity TCRs readily occurs provided high Ag doses are used, but IL-2 production and clonal expansion are severely reduced at all Ag doses. Remarkably, a single peptide variant can form an improved ligand for the highly diverse population of low-avidity self-specific T cells and can improve their proliferative capacity. These data provide insight into the inherent limitations of self-specific T cell responses through low-avidity TCR signals and the effect of modified peptide ligands on self-specific T cell immunity. | lld:pubmed |
| pubmed-article:11564799 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11564799 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11564799 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11564799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11564799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11564799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11564799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11564799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11564799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11564799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11564799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11564799 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11564799 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11564799 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11564799 | pubmed:author | pubmed-author:KruisbeekA... | lld:pubmed |
| pubmed-article:11564799 | pubmed:author | pubmed-author:SchumacherT... | lld:pubmed |
| pubmed-article:11564799 | pubmed:author | pubmed-author:de VisserK... | lld:pubmed |
| pubmed-article:11564799 | pubmed:author | pubmed-author:CordaroT ATA | lld:pubmed |
| pubmed-article:11564799 | pubmed:author | pubmed-author:TirionF HFH | lld:pubmed |
| pubmed-article:11564799 | pubmed:author | pubmed-author:KesselsH WHW | lld:pubmed |
| pubmed-article:11564799 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11564799 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11564799 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:11564799 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11564799 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11564799 | pubmed:pagination | 3818-28 | lld:pubmed |
| pubmed-article:11564799 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11564799 | pubmed:meshHeading | pubmed-meshheading:11564799... | lld:pubmed |
| pubmed-article:11564799 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11564799 | pubmed:articleTitle | Low-avidity self-specific T cells display a pronounced expansion defect that can be overcome by altered peptide ligands. | lld:pubmed |
| pubmed-article:11564799 | pubmed:affiliation | Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:11564799 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11564799 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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