Source:http://linkedlifedata.com/resource/pubmed/id/11564799
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2001-9-20
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| pubmed:abstractText |
Thymic expression of self-Ags results in the deletion of high-avidity self-specific T cells, but, at least for certain Ags, a residual population of self-specific T cells with low-affinity TCRs remains after negative selection. Such self-specific T cells are thought to play a role in the induction of T cell-mediated autoimmunity, but may also be used for the induction of antitumor immunity against self-Ags. In this study, we examine the functional competence of a polyclonal population of self-specific CD8+ T cells. We show that low-affinity interactions between TCR and peptide are associated with selective loss of critical T cell functions. Triggering of low levels of IFN-gamma production and cytolytic activity through low-affinity TCRs readily occurs provided high Ag doses are used, but IL-2 production and clonal expansion are severely reduced at all Ag doses. Remarkably, a single peptide variant can form an improved ligand for the highly diverse population of low-avidity self-specific T cells and can improve their proliferative capacity. These data provide insight into the inherent limitations of self-specific T cell responses through low-avidity TCR signals and the effect of modified peptide ligands on self-specific T cell immunity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/nucleoprotein (366-374), influenza...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
|
| pubmed:volume |
167
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3818-28
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11564799-Amino Acid Substitution,
pubmed-meshheading:11564799-Animals,
pubmed-meshheading:11564799-Autoantigens,
pubmed-meshheading:11564799-Autoimmunity,
pubmed-meshheading:11564799-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11564799-Cells, Cultured,
pubmed-meshheading:11564799-Cytokines,
pubmed-meshheading:11564799-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:11564799-Kinetics,
pubmed-meshheading:11564799-Ligands,
pubmed-meshheading:11564799-Lymphocyte Activation,
pubmed-meshheading:11564799-Mice,
pubmed-meshheading:11564799-Mice, Inbred C57BL,
pubmed-meshheading:11564799-Mice, Transgenic,
pubmed-meshheading:11564799-Peptide Fragments,
pubmed-meshheading:11564799-Peptides,
pubmed-meshheading:11564799-Receptors, Antigen, T-Cell,
pubmed-meshheading:11564799-Tumor Cells, Cultured,
pubmed-meshheading:11564799-Viral Core Proteins
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| pubmed:year |
2001
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| pubmed:articleTitle |
Low-avidity self-specific T cells display a pronounced expansion defect that can be overcome by altered peptide ligands.
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| pubmed:affiliation |
Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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