Linked Life Data

11564455

Source:http://linkedlifedata.com/resource/pubmed/id/11564455

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-9-20
pubmed:abstractText
A 48-h fast extends the estrous cycle of virgin rats and, when instituted on days 13 and 14 postpartum (pp), prolongs lactational infertility. We investigated the ability of 2-deoxy-D-glucose (2DG) alone or combined with mercaptoacetate (MA) to mimic these effects of fasting. In Experiment 1, we monitored estrous cyclicity in virgin rats receiving 800, 1200, or 1600 mg/kg/day of 2DG during metestrus and diestrus. In Experiment 2, we assessed the effects of 2DG (1600 mg/kg/day) given on days 13 and 14 pp, on the duration of lactational infertility. In Experiment 3, the combined effects of 2DG (1600, 2000, or 2400 mg/kg/day) and MA (180 mg/kg/day) on the length of lactational diestrus were evaluated. 2DG was sufficient to extend the estrous cycle of virgin rats, but neither 2DG alone nor given with MA prolonged the length of lactational diestrus. Results suggest that lactating rats are less sensitive than virgin rats to the effects of metabolic fuel inhibition on fertility. These data are discussed in relation to the hormonal state of the dam as well as in relation to the effects of these drugs on lactational performance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Effect of metabolic fuel availability on fertility varies with reproductive state.
pubmed:affiliation
Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, 7141 Sherbrooke Street West, H4B 1R6, Montreal, Quebec, Canada. alfabiz@vax2.concordia.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't