Linked Life Data

11564278

Source:http://linkedlifedata.com/resource/pubmed/id/11564278

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-9-20
pubmed:abstractText
We endeavor to show that the metabolism of the nonbeating heart can vary over an extreme range: from values approximating those measured in the beating heart to values of only a small fraction of normal--perhaps mimicking the situation of nonflow arrest during cardiac bypass surgery. We discuss some of the technical issues that make it difficult to establish the magnitude of basal metabolism in vivo. We consider some of the likely contributors to its magnitude and point out that the biochemical reasons for a sizable fraction of the heart's basal ATP usage remain unresolved. We consider many of the physiological factors that can alter the basal metabolic rate, stressing the importance of substrate supply. We point out that the protective effect of hypothermia may be less than is commonly assumed in the literature and suggest that hypoxia and ischemia may be able to regulate basal metabolic rate, thus making an important contribution to the phenomenon of cardiac hibernation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-521X
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
399-426
pubmed:dateRevised
2007-3-21
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Cardiac basal metabolism.
pubmed:affiliation
Department of Physiology, Faculty of Medicine, Nursing and Health Sciences, Monash University, PO Box 13F, Monash University, Victoria 3800, Australia. colin.gibbs@med.monash.edu.au
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't