Linked Life Data

11562411

Source:http://linkedlifedata.com/resource/pubmed/id/11562411

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-9-19
pubmed:abstractText
Diabetic nephropathy is a leading cause of end-stage renal failure. Its incidence is higher and is increasing in persons of Indo-Asian and African-Caribbean (African-Asian) compared with those of white origin. Nitric oxide deficiency is associated with progressive renal disease. It was hypothesized that differences in the capacity to increase glomerular filtration (functional renal reserve) would exist between these racial groups in relation to nitric oxide availability. Patients with type 2 diabetes of African-Asian (n = 9) and white (n = 9) origin with microalbuminuria were studied under euglycemic conditions. Glomerular filtration, renal plasma flow, and clearance of the stable metabolites of nitric oxide, nitrite, and nitrate were measured before and after a renal vasodilatory stimulus of a mixed amino acid intravenous infusion. There were no significant differences in age, duration of diabetes, and baseline glomerular filtration (57.1 [14.1] versus 55.8 [10.1] yr; P = 0.82, 14.5 [10.2] versus 9.1 [7.0] yr; P = 0.19 and 125.9 [30.9] versus 127.2 [44.6] ml/min per 1.73 m(2); P = 0.94) between the African-Asian and white groups. Functional renal reserve, change in renal plasma flow, and percentage change in nitrate and nitrite clearance was significantly higher in the white compared with the African-Asian group (21.9 [45.7] versus -2.5 [28.2] ml/min per 1.73 m(2); P = 0.043, 155.8 [205.9] versus -90.1 [146.0]; P = 0.03 ml/min per 1.73 m(2) and 26.7 [85.1] versus -44.7 [16.9] %; P = 0.013, respectively). The differences in functional reserve were not confounded after adjustment for diabetes duration (P = 0.034). The data suggest that these patients with type 2 diabetes of African and Asian origin lose functional renal reserve earlier in the evolution of nephropathy than whites. The differences appear to be due to defective nitric oxide production or bioavailability and might explain some of the propensity to develop end-stage renal disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1046-6673
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2125-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11562411-Africa, pubmed-meshheading:11562411-African Continental Ancestry Group, pubmed-meshheading:11562411-Aged, pubmed-meshheading:11562411-Albuminuria, pubmed-meshheading:11562411-Asian Continental Ancestry Group, pubmed-meshheading:11562411-Continental Population Groups, pubmed-meshheading:11562411-Diabetes Mellitus, Type 2, pubmed-meshheading:11562411-Ethnic Groups, pubmed-meshheading:11562411-European Continental Ancestry Group, pubmed-meshheading:11562411-Female, pubmed-meshheading:11562411-Humans, pubmed-meshheading:11562411-Kidney, pubmed-meshheading:11562411-Male, pubmed-meshheading:11562411-Middle Aged, pubmed-meshheading:11562411-Nitrates, pubmed-meshheading:11562411-Nitric Oxide, pubmed-meshheading:11562411-Nitrites, pubmed-meshheading:11562411-Renal Circulation
pubmed:year
2001
pubmed:articleTitle
Defective nitric oxide production and functional renal reserve in patients with type 2 diabetes who have microalbuminuria of African and Asian compared with white origin.
pubmed:affiliation
Royal Free and University College Medical School, Whittington Hospital, Department of Medicine, London N19 3UA, United Kingdom. k.earle@ucl.ac.uk
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't