Source:http://linkedlifedata.com/resource/pubmed/id/11561891
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0030608,
umls-concept:C0030685,
umls-concept:C0176751,
umls-concept:C0243144,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1450054,
umls-concept:C1521828,
umls-concept:C1522408,
umls-concept:C1697272,
umls-concept:C1704806,
umls-concept:C1963578
|
pubmed:issue |
21
|
pubmed:dateCreated |
2001-9-19
|
pubmed:abstractText |
Polyethyleneglycol (PEG)-coated polyethylcyanoacrylate (PECA) nanoparticles loaded with amoxicillin were prepared and the influence of the PEG coating on the particle size, zeta potential, drug release rate and phagocytic uptake by murine macrophages was studied. Experimental results show that this colloidal drug delivery system could be useful for intravenous or oral administration. The profile of amoxicillin release from PECA nanoparticles system was studied under various conditions similar to those of some corporeal fluids. In all these experiments, amoxicillin release in the free form was studied by HPLC analysis. Experimental results showed that at pH 7.4 drug release rises when molecular weight of PEG added to polymerization medium increases; in human plasma on the contrary drug release is reduced as molecular weight of PEG rises. Phagocytosis was evaluated by incubating amoxicillin-loaded PECA nanoparticles with murine macrophages and determining the amount of phagocytized nanoparticles by dosing the amoxicillin present inside the macrophages. The results of this study showed significative differences between nanoparticles prepared in the presence or in the absence of PEG and demonstrated that the PEG coating reduces the macrophages uptake. These results suggest that nanoparticles prepared in the presence of PEG are stealth carriers, which could be an injectable colloidal system able to avoid MPS recognition after intravenous injection. Experimental data of drug release at pH 1.1 and in the presence of urease, taking into account the mucoadhesive properties of polyalkylcyanoacrylate nanoparticles and the activity of the amoxicillin versus Helicobacter pylori, suggest moreover that the colloidal drug delivery system obtained in our laboratory could be useful for the treatment of diseases caused by H. pylori by peroral administration.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amoxicillin,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Cyanoacrylates,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Urease,
http://linkedlifedata.com/resource/pubmed/chemical/cyacrin
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0142-9612
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
22
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2857-65
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11561891-Amoxicillin,
pubmed-meshheading:11561891-Animals,
pubmed-meshheading:11561891-Biocompatible Materials,
pubmed-meshheading:11561891-Cyanoacrylates,
pubmed-meshheading:11561891-Drug Delivery Systems,
pubmed-meshheading:11561891-Drug Stability,
pubmed-meshheading:11561891-Humans,
pubmed-meshheading:11561891-Hydrogen-Ion Concentration,
pubmed-meshheading:11561891-Macrophages,
pubmed-meshheading:11561891-Mice,
pubmed-meshheading:11561891-Microspheres,
pubmed-meshheading:11561891-Particle Size,
pubmed-meshheading:11561891-Phagocytosis,
pubmed-meshheading:11561891-Polyethylene Glycols,
pubmed-meshheading:11561891-Urease
|
pubmed:year |
2001
|
pubmed:articleTitle |
Amoxicillin-loaded polyethylcyanoacrylate nanoparticles: influence of PEG coating on the particle size, drug release rate and phagocytic uptake.
|
pubmed:affiliation |
Dipartimento di Chimica e Tecnologie Farmaceutiche, Universitá di Palermo, Italy. gfontana@unipa.it
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|