Linked Life Data

11561846

Source:http://linkedlifedata.com/resource/pubmed/id/11561846

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-9-19
pubmed:abstractText
Penetration, metabolism, and excretion of radiocarbon were observed after topical treatment of Helicoverpa zea (Boddie), Spodoptera frugiperda (J. E. Smith), and Agrotis ipsilon (Hufnagle) larvae and adults with cypermethrin-14C. These pharmacokinetic events usually were higher with trans-cypermethrin-14C than with cis-cypermethrin-14C. They also were generally higher with H. zea and S. frugiperda than with A. ipsilon, and they were higher in larvae than in adults. No marked sex differences in the degradation of trans-cypermethrin were apparent. Pretreatment of H. zea, S. frugiperda, and A. ipsilon larvae and adults with S,S,S-tri-n-butyl phosphorotrithioate (DEF) 30 min before application of cypermethrin resulted in a perturbation of trans-cypermethrin pharmacokinetics manifested primarily by a lower rate of pyrethroid metabolism as compared with that in the absence of DEF. Appreciably higher internal levels of the toxic parent pyrethroid were often observed in the presence of DEF than in the absence of DEF in most cases. Suppression of cypermethrin penetration and elimination also was usually detected. Inhibition by DEF of the enzymatic degradation of cypermethrin may account for the synergy observed between these two compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-0493
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
874-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Pharmacokinetic mechanisms associated with synergism by DEF of cypermethrin toxicity in larval and adult Helicoverpa zea, Spodoptera frugiperda, and Agrotis ipsilon (Lepidoptera: Noctuidae).
pubmed:affiliation
Department of Entomology, University of Missouri, Columbia 65211, USA. kusmani@mailcity.com
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't