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pubmed-article:11561144pubmed:dateCreated2001-9-18lld:pubmed
pubmed-article:11561144pubmed:abstractTextThe lymphatic clearance of the human skin at the instep of the foot was measured in 20 healthy volunteers (mean age +/- SD 33.8 +/- 10.5 years). Ten microliters of fluorescein isothiocyanate-dextran 150,000 were injected intradermally and the fluorescent light intensity of the deposit was measured 10 min and 24 h after injection by window densitometry. Fluorescent light intensity decreased by 31.2 +/- 13.5 arbitrary units (p < 0.0001) or by a factor of 4.1 +/- 3.9. Reproducibility was tested 2-6 weeks later in 7 subjects and an intraclass reliability of 0.76 was found. These are the first measurements of the lymphatic clearance of the human skin using a fluorescent tracer. The method is easier and safer than the isotope clearance technique and small areas of the human skin can be investigated. The data found form a basis with which to compare measurements made in patients with different forms of edema.lld:pubmed
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pubmed-article:11561144pubmed:authorpubmed-author:HoffmannUUlld:pubmed
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pubmed-article:11561144pubmed:authorpubmed-author:FranzeckU KUKlld:pubmed
pubmed-article:11561144pubmed:authorpubmed-author:MINB CBClld:pubmed
pubmed-article:11561144pubmed:authorpubmed-author:HusmannM JMJlld:pubmed
pubmed-article:11561144pubmed:authorpubmed-author:FrisulloRRlld:pubmed
pubmed-article:11561144pubmed:copyrightInfoCopyright 2001 S. Karger AG, Basellld:pubmed
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pubmed-article:11561144pubmed:pagination423-31lld:pubmed
pubmed-article:11561144pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11561144pubmed:articleTitleMeasurement of the lymphatic clearance of the human skin using a fluorescent tracer.lld:pubmed
pubmed-article:11561144pubmed:affiliationDepartment of Internal Medicine, Angiology Division, University Hospital, Zürich, Switzerland.lld:pubmed
pubmed-article:11561144pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11561144pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed