Linked Life Data

11561068

Source:http://linkedlifedata.com/resource/pubmed/id/11561068

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-9-18
pubmed:abstractText
Octopamine, which is closely related to norepinephrine, acts as a neurotransmitter in invertebrates and is a trace amine with undefined properties in vertebrates. The octopaminergic receptors identified in insects are targets of various pesticides but are absent in vertebrates. We have established that octopamine stimulates fat cell lipolysis in mammals via activation of beta3-adrenoceptors (ARs), whereas this amine has been described elsewhere as an alpha2-AR agonist and as a substrate for monoamine oxidase (MAO) or semicarbazide-sensitive amine oxidase (SSAO). Because we have recently reported that amine oxidase substrates promote glucose transport in rat and human adipocytes, the in vitro octopamine effects on lipolysis and glucose uptake were reassessed by using adipocytes from beta3-AR-deficient mice. The lipolytic effect and the counter-regulation of insulin action on glucose transport provoked by 0.1 to 1 mM octopamine or by 1 microM beta3-AR agonists found in control animals disappeared in adipocytes from beta3-AR-deficient mice. This revealed an insulin-like effect of octopamine on glucose uptake, which was dependent on its oxidation by MAO or SSAO, as was the case for tyramine and benzylamine, devoid of beta3-adrenergic agonism. Similarly, octopamine promoted glucose transport in human adipocytes and exhibited a weaker lipolytic stimulation than in rodent adipocytes. These findings indicate that, besides its lipolytic activity, octopamine exerts, at millimolar dose, dual effect on glucose transport in adipocytes: counteracting insulin action via beta3-AR activation and stimulating basal transport via its oxidation by MAO or SSAO.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
299
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-104
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11561068-Adipocytes, pubmed-meshheading:11561068-Adrenergic alpha-Agonists, pubmed-meshheading:11561068-Adrenergic beta-3 Receptor Agonists, pubmed-meshheading:11561068-Amine Oxidase (Copper-Containing), pubmed-meshheading:11561068-Animals, pubmed-meshheading:11561068-Benzylamines, pubmed-meshheading:11561068-Cell Separation, pubmed-meshheading:11561068-Cells, Cultured, pubmed-meshheading:11561068-Glucose, pubmed-meshheading:11561068-Hexoses, pubmed-meshheading:11561068-Humans, pubmed-meshheading:11561068-Lipolysis, pubmed-meshheading:11561068-Mice, pubmed-meshheading:11561068-Monoamine Oxidase, pubmed-meshheading:11561068-Monoamine Oxidase Inhibitors, pubmed-meshheading:11561068-Octopamine, pubmed-meshheading:11561068-Oxidation-Reduction, pubmed-meshheading:11561068-Oxidoreductases Acting on CH-NH Group Donors, pubmed-meshheading:11561068-Tyramine
pubmed:year
2001
pubmed:articleTitle
Dual action of octopamine on glucose transport into adipocytes: inhibition via beta3-adrenoceptor activation and stimulation via oxidation by amine oxidases.
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale, Toulouse, France.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't