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rdf:type |
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lifeskim:mentions |
umls-concept:C0001779,
umls-concept:C0009373,
umls-concept:C0027651,
umls-concept:C0030705,
umls-concept:C0032580,
umls-concept:C0439793,
umls-concept:C0449258,
umls-concept:C1274040,
umls-concept:C1704686,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C2827666
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pubmed:issue |
4
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|
pubmed:dateCreated |
2001-9-17
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pubmed:abstractText |
As large scale genetic analysis becomes increasingly efficient, attention is turning to problems arising from inaccurate measurement of the phenotype. We have investigated the underlying basis of variation in disease severity in the large intestine of familial adenomatous polyposis (FAP) patients. The development of objective and reproducible measures may have future use in genetic studies, such as analysis of modifier genes.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0017-5749
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
540-3
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11559652-Adenomatous Polyposis Coli,
pubmed-meshheading:11559652-Adolescent,
pubmed-meshheading:11559652-Adult,
pubmed-meshheading:11559652-Age Factors,
pubmed-meshheading:11559652-Analysis of Variance,
pubmed-meshheading:11559652-Child,
pubmed-meshheading:11559652-Colectomy,
pubmed-meshheading:11559652-Female,
pubmed-meshheading:11559652-Genotype,
pubmed-meshheading:11559652-Humans,
pubmed-meshheading:11559652-Linear Models,
pubmed-meshheading:11559652-Male,
pubmed-meshheading:11559652-Phenotype,
pubmed-meshheading:11559652-Poisson Distribution
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pubmed:year |
2001
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pubmed:articleTitle |
Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age.
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pubmed:affiliation |
Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. mitch.crabstix@lineone.net
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pubmed:publicationType |
Journal Article
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