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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-9-14
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pubmed:abstractText |
In this study we report the activation of c-Jun N-terminal kinase (JNK) in human K562 erythroleukemia cells undergoing hemin-mediated erythroid differentiation, which occurs concomitantly with activation of heat shock factor 2 (HSF2) and leads to a simultaneous in vivo phosphorylation of c-Jun. The activation of JNK occurs through activation of mitogen-activated protein kinase kinase (MKK) 4 and not by activation of MKK7 or inhibition of JNK-directed phosphatases. We have previously shown that overexpression of the HSF2-beta isoform inhibits the activation of HSF2 upon hemin-induced erythroid differentiation. Here we demonstrate that HSF2-beta overexpression blocks the hemin-induced activation of the MKK4-JNK pathway, suggesting an erythroid lineage-specific JNK activation likely to be regulated by HSF2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anisomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/HSF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hemin,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun,
http://linkedlifedata.com/resource/pubmed/chemical/Staurosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
505
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
168-72
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11557063-Anisomycin,
pubmed-meshheading:11557063-Cell Differentiation,
pubmed-meshheading:11557063-Enzyme Activation,
pubmed-meshheading:11557063-Enzyme Inhibitors,
pubmed-meshheading:11557063-Erythroid Precursor Cells,
pubmed-meshheading:11557063-Heat-Shock Proteins,
pubmed-meshheading:11557063-Hemin,
pubmed-meshheading:11557063-Humans,
pubmed-meshheading:11557063-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:11557063-K562 Cells,
pubmed-meshheading:11557063-MAP Kinase Kinase 4,
pubmed-meshheading:11557063-MAP Kinase Kinase 7,
pubmed-meshheading:11557063-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:11557063-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11557063-Protein Isoforms,
pubmed-meshheading:11557063-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:11557063-Staurosporine,
pubmed-meshheading:11557063-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Activation of the MKK4-JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2-beta isoform.
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pubmed:affiliation |
Turku Centre for Biotechnology, University of Turku, Abo Akademi University, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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