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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0017372,
umls-concept:C0017638,
umls-concept:C0018270,
umls-concept:C0022660,
umls-concept:C0079419,
umls-concept:C0086418,
umls-concept:C0332291,
umls-concept:C0443224,
umls-concept:C0525037,
umls-concept:C0812222,
umls-concept:C0871261,
umls-concept:C1515926,
umls-concept:C1704632,
umls-concept:C1705280,
umls-concept:C1706817,
umls-concept:C2827404,
umls-concept:C2911692
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pubmed:issue |
9
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pubmed:dateCreated |
2001-9-13
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pubmed:abstractText |
EGR-1 is an immediate early gene with diverse functions that include the suppression of growth. EGR-1 is down-regulated many cancer cell types, suggesting a tumor suppressor role, and may critically involve the p53 pathway. The aim of this work was to measure the expression of EGR-1 and the p16/INK4a/ARF-Mdm2-p53 pathway status in fresh human gliomas.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/EGR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MDM2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-mdm2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p14ARF,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:ArcellaAA,
pubmed-author:CalogeroAA,
pubmed-author:CarusoRR,
pubmed-author:De GregorioGG,
pubmed-author:FratiLL,
pubmed-author:GagliardiF MFM,
pubmed-author:GianniniGG,
pubmed-author:GulinoAA,
pubmed-author:LisMM,
pubmed-author:LombariVV,
pubmed-author:MercolaDD,
pubmed-author:PorcelliniAA,
pubmed-author:RagonaGG,
pubmed-author:ZangOO
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2788-96
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11555594-Blotting, Northern,
pubmed-meshheading:11555594-Brain Neoplasms,
pubmed-meshheading:11555594-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:11555594-DNA, Neoplasm,
pubmed-meshheading:11555594-DNA Mutational Analysis,
pubmed-meshheading:11555594-DNA-Binding Proteins,
pubmed-meshheading:11555594-Down-Regulation,
pubmed-meshheading:11555594-Early Growth Response Protein 1,
pubmed-meshheading:11555594-Gene Deletion,
pubmed-meshheading:11555594-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11555594-Glioma,
pubmed-meshheading:11555594-Humans,
pubmed-meshheading:11555594-Immediate-Early Proteins,
pubmed-meshheading:11555594-Immunohistochemistry,
pubmed-meshheading:11555594-Mutation, Missense,
pubmed-meshheading:11555594-Nuclear Proteins,
pubmed-meshheading:11555594-Proteins,
pubmed-meshheading:11555594-Proto-Oncogene Proteins,
pubmed-meshheading:11555594-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:11555594-RNA, Messenger,
pubmed-meshheading:11555594-RNA, Neoplasm,
pubmed-meshheading:11555594-Transcription Factors,
pubmed-meshheading:11555594-Tumor Suppressor Protein p14ARF,
pubmed-meshheading:11555594-Tumor Suppressor Protein p53
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pubmed:year |
2001
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pubmed:articleTitle |
The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas.
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pubmed:affiliation |
Department of Molecular Pathology, Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli, 86077 Italy. calognant@neuromed.it
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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