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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-9-13
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pubmed:abstractText |
Human immunodeficiency virus type 1 (HIV-1) Tat repressed the p53-dependent gene expression through its C-terminal domain of Tat (amino acid residues 73-86) independent of the involvement of NF-kappaB and coactivator CBP/p300. Although Tat did not directly bind to p53, this repression required the N-terminal domain of p53. In contrast, Tat and p53 cooperated in the activation of HIV-1 gene expression. Thus, the cross-talk between Tat and p53 may be linked with cellular transformation by HIV-1 infection or activation of HIV-1 replication.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
287
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
556-61
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11554765-Animals,
pubmed-meshheading:11554765-COS Cells,
pubmed-meshheading:11554765-Gene Expression,
pubmed-meshheading:11554765-Gene Products, tat,
pubmed-meshheading:11554765-Gene Silencing,
pubmed-meshheading:11554765-HIV Long Terminal Repeat,
pubmed-meshheading:11554765-HIV-1,
pubmed-meshheading:11554765-NF-kappa B,
pubmed-meshheading:11554765-Protein Structure, Tertiary,
pubmed-meshheading:11554765-Transcriptional Activation,
pubmed-meshheading:11554765-Tumor Suppressor Protein p53,
pubmed-meshheading:11554765-Virus Replication,
pubmed-meshheading:11554765-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2001
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pubmed:articleTitle |
Functional cross-talk of HIV-1 Tat with p53 through its C-terminal domain.
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pubmed:affiliation |
Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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