Source:http://linkedlifedata.com/resource/pubmed/id/11553856
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2001-9-12
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| pubmed:abstractText |
The role of circulating tumor markers in providing prognostic information has not been widely studied. In the current study, serum levels of the carbohydrate antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) were determined preoperatively in 364 breast cancer patients with no clinical signs of metastasis. The prognostic relevance of these markers for recurrence (175/364) and death of disease (104/175) was determined by Cox multivariate analysis, including the comparison with classical prognostic factors. High levels of both tumor markers were associated with aneuploid tumors with high S-phase fraction and high ornithine decarboxylase activity. CA 15-3 was highly associated with the number of positive lymph nodes and peritumoral lymphatic or blood vessel invasion. No significant associations were found between CEA or CA 15-3 levels and histologic grade, necrosis and steroid receptor status. In univariate analysis, preoperative values, using optimum cutoff values of CA 15-3 (40 U/ml) and CEA (6 ng/ml), were statistically significant for relapse-free survival and overall survival. In multivariate analysis, only node status, DNA ploidy and ornithine decarboxylase activity were independent predictors for relapse-free survival; the estrogen receptor status was a predictor of overall survival. In node-negative patients, ornithine decarboxylase activity was the only factor selected for relapse-free survival. In node-positive patients, the number of lymph nodes and DNA ploidy were the only variables selected for relapse-free survival or overall survival. Estrogen receptor and ornithine decarboxylase activity were excluded for relapse-free survival, but were significant prognostic factors for overall survival.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carcinoembryonic Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Mucin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Ornithine Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1010-4283
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2001 S. Karger AG, Basel
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| pubmed:issnType |
Print
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
273-81
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11553856-Adult,
pubmed-meshheading:11553856-Aged,
pubmed-meshheading:11553856-Aneuploidy,
pubmed-meshheading:11553856-Breast Neoplasms,
pubmed-meshheading:11553856-Carcinoembryonic Antigen,
pubmed-meshheading:11553856-Cell Cycle,
pubmed-meshheading:11553856-DNA, Neoplasm,
pubmed-meshheading:11553856-Diploidy,
pubmed-meshheading:11553856-Female,
pubmed-meshheading:11553856-Flow Cytometry,
pubmed-meshheading:11553856-Humans,
pubmed-meshheading:11553856-Lymphatic Metastasis,
pubmed-meshheading:11553856-Menopause,
pubmed-meshheading:11553856-Middle Aged,
pubmed-meshheading:11553856-Mucin-1,
pubmed-meshheading:11553856-Multivariate Analysis,
pubmed-meshheading:11553856-Necrosis,
pubmed-meshheading:11553856-Ornithine Decarboxylase,
pubmed-meshheading:11553856-Prognosis,
pubmed-meshheading:11553856-Receptors, Estrogen,
pubmed-meshheading:11553856-Receptors, Progesterone,
pubmed-meshheading:11553856-Recurrence,
pubmed-meshheading:11553856-Retrospective Studies,
pubmed-meshheading:11553856-Survival Rate,
pubmed-meshheading:11553856-Tumor Markers, Biological
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| pubmed:articleTitle |
Preoperative values of CA 15-3 and CEA as prognostic factors in breast cancer: a multivariate analysis.
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| pubmed:affiliation |
Department of Clinical Chemistry, University Hospital Virgen de la Arrixaca, Murcia, Spain. fcanizares@hvax.insalud.es
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| pubmed:publicationType |
Journal Article
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