Source:http://linkedlifedata.com/resource/pubmed/id/11553047
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2001-9-12
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| pubmed:abstractText |
Association between apolipoprotein E (apoE) gene polymorphism and lipid levels was studied in 164 nondiabetic first-degree relatives of persons with diabetes and 962 nondiabetic persons with no family history of diabetes. Sex-specific genotypic distribution of apoE polymorphism did not differ between persons with and without a family history of diabetes. In first-degree relatives, lipid levels did not differ among persons with apoE2 (E2/2, E2/3), apoE3/3, and apoE4 (E4/4, E3/4) after adjusting for age, waist circumference, smoking, and alcohol and estrogen use. In persons without a family history of diabetes, both men (p<0.01) and women (p<0.001) with apoE2 showed lower levels of total and low density lipoprotein cholesterol compared with persons with apoE3/3 and apoE4. In women with a family history of diabetes, persons with apoE4 had larger waist circumference (p<0.05). ApoE2 allele is associated with more favorable levels of total and low density lipoprotein cholesterol in men and women without a family history of diabetes. ApoE4 allele is associated with obesity independent of dyslipidemia in women but not men with a family history of diabetes. ApoE polymorphism is not associated with lipids in men or women with a family history of diabetes.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
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| pubmed:issn |
0009-9163
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
60
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
132-7
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11553047-Aged,
pubmed-meshheading:11553047-Alleles,
pubmed-meshheading:11553047-Analysis of Variance,
pubmed-meshheading:11553047-Apolipoproteins E,
pubmed-meshheading:11553047-Body Constitution,
pubmed-meshheading:11553047-Body Mass Index,
pubmed-meshheading:11553047-DNA,
pubmed-meshheading:11553047-Diabetes Mellitus, Type 2,
pubmed-meshheading:11553047-Family Health,
pubmed-meshheading:11553047-Female,
pubmed-meshheading:11553047-Gene Frequency,
pubmed-meshheading:11553047-Genotype,
pubmed-meshheading:11553047-Glucose Tolerance Test,
pubmed-meshheading:11553047-Humans,
pubmed-meshheading:11553047-Lipid Metabolism,
pubmed-meshheading:11553047-Male,
pubmed-meshheading:11553047-Middle Aged,
pubmed-meshheading:11553047-Polymorphism, Genetic,
pubmed-meshheading:11553047-Sex Factors
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Apolipoprotein E polymorphism and lipid levels differ by gender and family history of diabetes: the Rancho Bernardo Study.
|
| pubmed:affiliation |
Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0607, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|