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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1975-11-6
|
| pubmed:abstractText |
In experimental yellow fever virus encephalomyelitis of adult albino mice, virions, and virus-associated structures were observed not only inside neuronal perikarya but also within dendrites of varied size. The finding permits the following explanations: (1) either the viral agent is synthesized in the nerve cell bodies and transported intradendritically in a proximodistal direction; or (2) virus morphogenesis takes place in neuronal perikarya and dendrites as well; or (3) both possiblities are equally valid. Some incidental findings were suggestive of virus release at postsynaptic dendrite membranes. They are discussed with reference to a hypothetical long-distance pathway of viral dissemination involving endocytosis of the agent by presynaptic axon terminals, intraaxonal virus decoating, and retrograde axoplasmic transport of the infectious nucleic acid to the cell soma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0091-3952
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
459-64
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1155274-Animals,
pubmed-meshheading:1155274-Central Nervous System,
pubmed-meshheading:1155274-Dendrites,
pubmed-meshheading:1155274-Encephalomyelitis,
pubmed-meshheading:1155274-Inclusion Bodies, Viral,
pubmed-meshheading:1155274-Mice,
pubmed-meshheading:1155274-Synapses,
pubmed-meshheading:1155274-Yellow Fever,
pubmed-meshheading:1155274-Yellow fever virus
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
Virions and virus-associated structures within dendrites in an experimental flavovirus encephalomyelitis.
|
| pubmed:publicationType |
Journal Article
|