Source:http://linkedlifedata.com/resource/pubmed/id/11550157
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-9-10
|
| pubmed:abstractText |
Telomerase activation is believed to play a critical role in the immortalization of cells and carcinogenesis. Telomerase activity is undetectable in normal somatic cells (except for those cells undergoing proliferation) but is expressed in the majority of human tumors including lung carcinoma. The expression of hTERT mRNA has been found to be correlated with telomerase activity. In the current study, the authors analyzed telomerase activity and hTERT mRNA expression in preinvasive bronchial lesions using biopsy specimens obtained by fluorescence bronchoscopy.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0008-543X
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2001 American Cancer Society.
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
92
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
849-55
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11550157-Adult,
pubmed-meshheading:11550157-Aged,
pubmed-meshheading:11550157-Aged, 80 and over,
pubmed-meshheading:11550157-Biopsy,
pubmed-meshheading:11550157-Bronchi,
pubmed-meshheading:11550157-Bronchoscopy,
pubmed-meshheading:11550157-Carcinoma, Squamous Cell,
pubmed-meshheading:11550157-DNA-Binding Proteins,
pubmed-meshheading:11550157-Female,
pubmed-meshheading:11550157-Fluorescence,
pubmed-meshheading:11550157-Gene Expression,
pubmed-meshheading:11550157-Humans,
pubmed-meshheading:11550157-Lung Neoplasms,
pubmed-meshheading:11550157-Male,
pubmed-meshheading:11550157-Metaplasia,
pubmed-meshheading:11550157-Middle Aged,
pubmed-meshheading:11550157-Precancerous Conditions,
pubmed-meshheading:11550157-RNA, Messenger,
pubmed-meshheading:11550157-Telomerase
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Increased telomerase activity and elevated hTERT mRNA expression during multistage carcinogenesis of squamous cell carcinoma of the lung.
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| pubmed:affiliation |
Department of Surgery, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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