Linked Life Data

11550009

Source:http://linkedlifedata.com/resource/pubmed/id/11550009

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-9-28
pubmed:abstractText
The natural killer (NK) cell activation receptor Ly49H is required for resistance to murine cytomegalovirus (MCMV). We show here that NK cell proliferation and production of interferon-gamma (IFN-gamma) was not dependent on Ly49H expression during early MCMV infection. During a later phase of infection, however, Ly49H+ NK cells selectively proliferated and this expansion was blocked by anti-Ly49H administration. With vaccinia virus infection, neither the early nor late phase of NK cell proliferation was selective for Ly49H+ NK cells. These findings indicated that Ly49H+ NK cells were specifically activated by MCMV and that MCMV infection was characterized by nonspecific and specific phases of NK cell activation in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1529-2908
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
951-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11550009-Animals, pubmed-meshheading:11550009-Antibodies, Monoclonal, pubmed-meshheading:11550009-Antigens, Ly, pubmed-meshheading:11550009-Cells, Cultured, pubmed-meshheading:11550009-Herpesviridae Infections, pubmed-meshheading:11550009-Interferon-gamma, pubmed-meshheading:11550009-Killer Cells, Natural, pubmed-meshheading:11550009-Kinetics, pubmed-meshheading:11550009-Lectins, C-Type, pubmed-meshheading:11550009-Lymphocyte Activation, pubmed-meshheading:11550009-Lymphocyte Subsets, pubmed-meshheading:11550009-Membrane Glycoproteins, pubmed-meshheading:11550009-Mice, pubmed-meshheading:11550009-Mice, Inbred C57BL, pubmed-meshheading:11550009-NK Cell Lectin-Like Receptor Subfamily A, pubmed-meshheading:11550009-Receptors, NK Cell Lectin-Like, pubmed-meshheading:11550009-Vaccinia
pubmed:year
2001
pubmed:articleTitle
Specific and nonspecific NK cell activation during virus infection.
pubmed:affiliation
Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't