|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
18
|
|
pubmed:dateCreated |
2001-9-10
|
|
pubmed:abstractText |
Readily derived from D-glucose, 5-[(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-2-methyl-3-furoic esters and amides are selective and competitive inhibitors (K(i)> or = 3 microM) of alpha-L-fucosidase from bovine epididymis and from human placenta.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2555-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11549468-Animals,
pubmed-meshheading:11549468-Cattle,
pubmed-meshheading:11549468-Drug Design,
pubmed-meshheading:11549468-Drug Evaluation, Preclinical,
pubmed-meshheading:11549468-Enzyme Inhibitors,
pubmed-meshheading:11549468-Epididymis,
pubmed-meshheading:11549468-Female,
pubmed-meshheading:11549468-Furans,
pubmed-meshheading:11549468-Inhibitory Concentration 50,
pubmed-meshheading:11549468-Male,
pubmed-meshheading:11549468-Placenta,
pubmed-meshheading:11549468-Pregnancy,
pubmed-meshheading:11549468-alpha-L-Fucosidase
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives.
|
|
pubmed:affiliation |
Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, E-41071, Sevilla, Spain. pierre.vogel@ico.unil.ch
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
