Source:http://linkedlifedata.com/resource/pubmed/id/11549462
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
18
|
| pubmed:dateCreated |
2001-9-10
|
| pubmed:abstractText |
The synthesis of a new family of A1-adenosine receptor (A1AR) ligands 3a-n has been performed in a straightforward way. Affinity data at A1AR, A2AAR and A3AR in bovine membranes show that these new compounds bind the A1AR in a selective way over A2AAR and A3AR and one of them (3j) presents a very high affinity, probably due to the phenethylamine substituent at C-4.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
17
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2529-31
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11549462-Animals,
pubmed-meshheading:11549462-Cattle,
pubmed-meshheading:11549462-Drug Design,
pubmed-meshheading:11549462-Drug Evaluation, Preclinical,
pubmed-meshheading:11549462-Ligands,
pubmed-meshheading:11549462-Pyrazoles,
pubmed-meshheading:11549462-Pyridines,
pubmed-meshheading:11549462-Receptors, Purinergic P1,
pubmed-meshheading:11549462-Structure-Activity Relationship
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands.
|
| pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia dell'Università degli Studi di Genova, Viale Benedetto XV, 3, 16132, Genoa, Italy. schensil@unige.it
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|