Source:http://linkedlifedata.com/resource/pubmed/id/11549403
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
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| pubmed:dateCreated |
2001-9-10
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| pubmed:abstractText |
Cholecystokinin A receptors (CCKAR) modulate CCK-stimulated dopamine release, and mutations in the CCKAR gene may predispose affected individuals to schizophrenia. Our previous study suggested that -286A>G polymorphism (previously named 201A>G) in the CCKAR gene promoter is associated with schizophrenia. In the present study, we carried out a further investigation of the promoter and intron 1 of the CCKAR gene. In addition to polymorphisms reported previously (-333G>T, -286A>G, -241G>A, 773A>T, and 779T>C), two novel polymorphisms (-388(GT)(8)>(GT)(9) and -85C>G) were identified. These polymorphisms were in a linkage disequilibrium. Association analyses between schizophrenic patients and controls revealed that the frequencies of the A allele and AA genotype at the -286 loci, as well as the frequency of the GG genotype at the -333 loci, were significantly higher in patients than in controls. Furthermore, patients with paranoid type schizophrenia, auditory hallucinations, or a positive family history had a significantly higher frequency of the -286A allele than the control group. The results supported our previous data, and suggest the possible involvement of the -333G>T and the -286A>G polymorphisms in the promoter region of the CCKAR gene in the predisposition to schizophrenia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
0165-1781
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
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| pubmed:volume |
103
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
147-55
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11549403-Adult,
pubmed-meshheading:11549403-Aged,
pubmed-meshheading:11549403-Alleles,
pubmed-meshheading:11549403-Female,
pubmed-meshheading:11549403-Gene Frequency,
pubmed-meshheading:11549403-Genetic Predisposition to Disease,
pubmed-meshheading:11549403-Genotype,
pubmed-meshheading:11549403-Hallucinations,
pubmed-meshheading:11549403-Heterozygote Detection,
pubmed-meshheading:11549403-Humans,
pubmed-meshheading:11549403-Introns,
pubmed-meshheading:11549403-Linkage Disequilibrium,
pubmed-meshheading:11549403-Male,
pubmed-meshheading:11549403-Middle Aged,
pubmed-meshheading:11549403-Phenotype,
pubmed-meshheading:11549403-Polymorphism, Genetic,
pubmed-meshheading:11549403-Promoter Regions, Genetic,
pubmed-meshheading:11549403-Psychiatric Status Rating Scales,
pubmed-meshheading:11549403-Receptor, Cholecystokinin A,
pubmed-meshheading:11549403-Receptors, Cholecystokinin,
pubmed-meshheading:11549403-Schizophrenia,
pubmed-meshheading:11549403-Schizophrenia, Paranoid
|
| pubmed:year |
2001
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| pubmed:articleTitle |
Linked polymorphisms (-333G>T and -286A>G) in the promoter region of the CCK-A receptor gene may be associated with schizophrenia.
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| pubmed:affiliation |
Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan. praecox@mail1.accsnet.ne.jp
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| pubmed:publicationType |
Journal Article
|