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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0010097,
umls-concept:C0026336,
umls-concept:C0034693,
umls-concept:C0162512,
umls-concept:C0205223,
umls-concept:C0205349,
umls-concept:C0207072,
umls-concept:C1327616,
umls-concept:C1333669,
umls-concept:C1527362
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pubmed:issue |
4-5
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pubmed:dateCreated |
2001-9-10
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pubmed:abstractText |
In order to deliver glial cell line-derived neurotrophic factor (GDNF) into the brain, we have established a cell line that produces GDNF in a continuous fashion by genetic engineering. These cells were encapsulated and grafted into parkinsonian model rats that had received unilateral intrastriatal injection of 6-hydroxydopamine 2 weeks earlier. Neurochemical analysis showed that GDNF has been produced from the capsule for 6 months after grafting and histological analysis revealed good survival of GDNF-producing cells in the capsule 6 months after grafting. The density of nigrostriatal dopaminergic fibers in the striatum as well as the number of dopaminergic cell bodies in the substantia nigra recovered significantly after GDNF-producing cell grafting. These results suggest the possible application of GDNF-producing cell grafting for the treatment of Parkinson's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0963-6897
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
397-401
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11549061-Animals,
pubmed-meshheading:11549061-Capsules,
pubmed-meshheading:11549061-Cell Line,
pubmed-meshheading:11549061-Cell Transplantation,
pubmed-meshheading:11549061-Cricetinae,
pubmed-meshheading:11549061-Disease Models, Animal,
pubmed-meshheading:11549061-Dopamine,
pubmed-meshheading:11549061-Genetic Engineering,
pubmed-meshheading:11549061-Glial Cell Line-Derived Neurotrophic Factor,
pubmed-meshheading:11549061-Humans,
pubmed-meshheading:11549061-Nerve Growth Factors,
pubmed-meshheading:11549061-Nerve Tissue Proteins,
pubmed-meshheading:11549061-Neurons,
pubmed-meshheading:11549061-Neuropsychological Tests,
pubmed-meshheading:11549061-Parkinsonian Disorders,
pubmed-meshheading:11549061-Rats,
pubmed-meshheading:11549061-Rats, Sprague-Dawley,
pubmed-meshheading:11549061-Transfection,
pubmed-meshheading:11549061-Transplantation, Heterologous,
pubmed-meshheading:11549061-Visual Cortex
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pubmed:year |
2001
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pubmed:articleTitle |
Grafting of encapsulated genetically modified cells secreting GDNF into the striatum of parkinsonian model rats.
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pubmed:affiliation |
Department of Neurological Surgery, Okayama University Medical School, Japan. idate333@med.okayama-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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