rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
13
|
pubmed:dateCreated |
2001-9-7
|
pubmed:abstractText |
We report the long-term outcome of 27 HIV-infected patients treated for over 3 years with IL-2 and binucleoside analogues. These patients experienced a sustained increase in CD4 cells and a decrease of proviral DNA with infrequent IL-2 cycles. In three cases, virus could not be isolated from activated peripheral cells. A high frequency of HIV-1-specific memory CD4 T cells was found in the patients studied. IL-2 maintains specific effector cells and reduces the pool of infected cells in patients, albeit treated only with binucleosides.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0269-9370
|
pubmed:author |
pubmed-author:ANRS 048 Study Group,
pubmed-author:BouchenafaKK,
pubmed-author:BurgardMM,
pubmed-author:CapitantCC,
pubmed-author:DelfraissyJ FJF,
pubmed-author:GougeonM LML,
pubmed-author:LeviII,
pubmed-author:LibermanII,
pubmed-author:RouziouxCC,
pubmed-author:TaoufikYY,
pubmed-author:ViardJ PJP
|
pubmed:issnType |
Print
|
pubmed:day |
7
|
pubmed:volume |
15
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1729-31
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11546950-Anti-HIV Agents,
pubmed-meshheading:11546950-CD4 Lymphocyte Count,
pubmed-meshheading:11546950-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11546950-DNA, Viral,
pubmed-meshheading:11546950-Didanosine,
pubmed-meshheading:11546950-Drug Therapy, Combination,
pubmed-meshheading:11546950-HIV Infections,
pubmed-meshheading:11546950-HIV-1,
pubmed-meshheading:11546950-Humans,
pubmed-meshheading:11546950-Immunologic Memory,
pubmed-meshheading:11546950-Interleukin-2,
pubmed-meshheading:11546950-Reverse Transcriptase Inhibitors,
pubmed-meshheading:11546950-Time Factors,
pubmed-meshheading:11546950-Zidovudine
|
pubmed:year |
2001
|
pubmed:articleTitle |
Immunological and virological effects of long term IL-2 therapy in HIV-1-infected patients.
|
pubmed:affiliation |
Département SIDA et Rétrovirus, Institut Pasteur, Paris, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|