| pubmed-article:11546812 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11546812 | lifeskim:mentions | umls-concept:C0887904 | lld:lifeskim |
| pubmed-article:11546812 | lifeskim:mentions | umls-concept:C0010531 | lld:lifeskim |
| pubmed-article:11546812 | lifeskim:mentions | umls-concept:C1332071 | lld:lifeskim |
| pubmed-article:11546812 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:11546812 | pubmed:issue | 47 | lld:pubmed |
| pubmed-article:11546812 | pubmed:dateCreated | 2001-11-19 | lld:pubmed |
| pubmed-article:11546812 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11546812 | pubmed:abstractText | Guanine nucleotide exchange factors of the Dbl family relay signals from membrane receptors to Rho family GTPases. We now demonstrate that a longer transcript of the Lbc gene encodes a chimeric molecule, which we have called AKAP-Lbc, that functions as an A-kinase-anchoring protein (AKAP) and a Rho-selective guanine nucleotide exchange factor. Expression of AKAP-Lbc in fibroblasts favors the formation of stress fibers in a Rho-dependent manner. Application of lysophosphatidic acid or selective expression of Galpha(12) enhances cellular AKAP-Lbc activation. Furthermore, biochemical studies indicate that AKAP-Lbc functions as an adaptor protein to selectively couple Galpha(12) to Rho. Thus, AKAP-Lbc anchors PKA and nucleates the assembly of a Rho-mediated signaling pathway. | lld:pubmed |
| pubmed-article:11546812 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11546812 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11546812 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11546812 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11546812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11546812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11546812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11546812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11546812 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11546812 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11546812 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11546812 | pubmed:author | pubmed-author:ScottJ DJD | lld:pubmed |
| pubmed-article:11546812 | pubmed:author | pubmed-author:DivianiDD | lld:pubmed |
| pubmed-article:11546812 | pubmed:author | pubmed-author:SoderlingJJ | lld:pubmed |
| pubmed-article:11546812 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11546812 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:11546812 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11546812 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11546812 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11546812 | pubmed:pagination | 44247-57 | lld:pubmed |
| pubmed-article:11546812 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:meshHeading | pubmed-meshheading:11546812... | lld:pubmed |
| pubmed-article:11546812 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11546812 | pubmed:articleTitle | AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. | lld:pubmed |
| pubmed-article:11546812 | pubmed:affiliation | Howard Hughes Medical Institute, Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA. | lld:pubmed |
| pubmed-article:11546812 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11546812 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:388 | entrezgene:pubmed | pubmed-article:11546812 | lld:entrezgene |
| entrez-gene:389 | entrezgene:pubmed | pubmed-article:11546812 | lld:entrezgene |
| entrez-gene:2768 | entrezgene:pubmed | pubmed-article:11546812 | lld:entrezgene |
| entrez-gene:11214 | entrezgene:pubmed | pubmed-article:11546812 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11546812 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11546812 | lld:pubmed |
