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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-9-6
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pubmed:abstractText |
It has become increasingly apparent in studies of mutant mice and observations of disease that cytokine production by fully committed effector T cells within the Th1 and Th2 phenotype can vary within each group. This can potentially influence the type and effectiveness of a given immune response. The factors responsible for inducing variable Th1 and Th2 subtype responses have not been well established. Using transgenic mice expressing the myelin basic protein-specific TCR, we demonstrate here that two distinct populations of Th2 cells that are characterized primarily by differential IL-4 and IL-5 expression levels can be generated depending upon the levels of IFN-gamma present at the time of priming. We also demonstrate that populations expressing high levels of IL-4 relative to IL-5 vs those with intermediate levels of IL-4 relative to IL-5 are stable and possess distinct effector functions in an experimental autoimmune encephalomyelitis model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3074-81
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11544291-Adoptive Transfer,
pubmed-meshheading:11544291-Animals,
pubmed-meshheading:11544291-Autoimmune Diseases,
pubmed-meshheading:11544291-Autoimmunity,
pubmed-meshheading:11544291-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:11544291-Gene Expression Profiling,
pubmed-meshheading:11544291-Homeodomain Proteins,
pubmed-meshheading:11544291-Interferon-gamma,
pubmed-meshheading:11544291-Interleukin-4,
pubmed-meshheading:11544291-Interleukin-5,
pubmed-meshheading:11544291-Lymphokines,
pubmed-meshheading:11544291-Mice,
pubmed-meshheading:11544291-Mice, Inbred C57BL,
pubmed-meshheading:11544291-Mice, Knockout,
pubmed-meshheading:11544291-Mice, Transgenic,
pubmed-meshheading:11544291-Myelin Basic Proteins,
pubmed-meshheading:11544291-Phenotype,
pubmed-meshheading:11544291-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:11544291-Specific Pathogen-Free Organisms,
pubmed-meshheading:11544291-Th1 Cells,
pubmed-meshheading:11544291-Th2 Cells
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pubmed:year |
2001
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pubmed:articleTitle |
The role of IFN-gamma in the production of Th2 subpopulations: implications for variable Th2-mediated pathologies in autoimmunity.
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pubmed:affiliation |
Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University Medical Center, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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