Linked Life Data

11542340

Source:http://linkedlifedata.com/resource/pubmed/id/11542340

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-11-7
pubmed:abstractText
The major objective of several experiments performed in space in the last 15 years was to establish whether single cells are sensitive to gravity. It was found in certain cells that reduced gravity leads to profound changes of a number of physiological functions like genetic expression, cell proliferation, signal transduction and cytoskeleton structure. In cell biology studies microgravity can be simulated on Earth in the clinostat. Nearly all data on experiments in the clinostat are related to cells cultured in suspension and, therefore, to adhesion-independent cells. In contrast, several biological phenomena as neoplastic transformation, cell differentiation, in-vitro cellular aging, contact inhibition and cellular adhesion require mainly cellular systems that are adhesion-dependent. The purpose of this work was: a) to study the behaviour of two rat cell strains (neoplastic SGS/4A and syngeneic fibroblasts FG) in order to test whether adhesion-dependent cells are suitable for clinorotation and b) to investigate cell-cell and cell-substratum adhesion in these cells kept under simulated low-g in the fast rotating clinostat and in hypergravity at l0g in the centrifuge.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
S
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1077-9248
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NASA
pubmed:authorsComplete
Y
pubmed:pagination
P165-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Cellular adhesion in neoplastic and syngeneic normal cells under altered gravitational conditions.
pubmed:affiliation
Dipartimento di Scienze Fisiologiche, Biochimiche e Cellulari; Universita di Sassari.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't