Linked Life Data

1153942

Source:http://linkedlifedata.com/resource/pubmed/id/1153942

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1975-11-6
pubmed:abstractText
Sodium carboxyl-14C acetylsalicylate was injected intravenously into fasted rats in which gastric secretion was either inhibited by atropine or stimulated by histamine. After one hour blood samples and specimens from the glandular portion of the gastric mucosa, muscle, liver, and kidney were taken. The 14C activity in the blood and specimens was determined by liquid scintillation counting after combustion. The drug concentration was lowest in muscle and gastric mucosa, intermediate in the liver, and highest in the kidney, where it equalled that in the blood. The concentrations were proportional to the amount of drug injected in all the examined tissues. There was no difference between rats given histamine and those given atropine. The secretory state of the gastric mucosa thus did not affect the concentration of the drug in this tissue when acetylsalicylate was given intravenously.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0036-5521
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
465-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Distribution of intravenous sodium acetylsalicylate in the unanaesthetized rat on stimulation and inhibition of gastric secretion.
pubmed:publicationType
Journal Article