Linked Life Data

11539012

Source:http://linkedlifedata.com/resource/pubmed/id/11539012

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Suppl
pubmed:dateCreated
1997-10-10
pubmed:abstractText
Cardiovascular responses and fluid/electrolyte shifts seen during spaceflight have been attributed to cephalad redistribution of vascular fluid. The antiorthostatic (AO) rat (suspended, head-down tilt of 15-20 degrees) is used to model these responses. This study documents that elevated blood pressures in AO rats are sustained for periods of up to seven days, compared with presuspension values. Increased blood pressures in AO rats suggests a specific response to AO positioning, potentially relatable to a cephalad fluid shift. To assess a role for hormonal regulation of sodium excretion, serum aldosterone levels were measured. Circulating aldosterone concentrations were seen to increase approximately 100% during seven days of AO suspension concurrently with a pronounced natriuresis. These results suggest that aldosterone many not be involved in the long term regulation of increased Na+ excretion in AO animals. These studies continue to show the usefulness of models for the development of animal protocols for space flight.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
S
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0031-9376
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NASA
pubmed:authorsComplete
Y
pubmed:pagination
S41-2
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Cardiovascular and hormonal (aldosterone) responses in a rat model which mimics responses to weightlessness.
pubmed:affiliation
Dept. Physiology and Biophysics, University of Louisville, Kentucky 40292, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.