Linked Life Data

11537710

Source:http://linkedlifedata.com/resource/pubmed/id/11537710

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1996-2-13
pubmed:abstractText
Incubation of murine fibroblasts with orthovanadate, a global tyrosine phosphatase inhibitor, was shown to confer a "pseudo-transformed" phenotype with regard to cell morphology and growth characteristics. This alteration was manifested by both an increasing refractile appearance of the cells, consistent with many transformed cell lines, as well as an increase in maximum cell density was attained. Despite the abrogation of cellular tyrosine phosphatase activity, orthovanadate-treated cells remained sensitive to the biological activity of a naturally occurring sialoglycopeptide (SGP) cell surface proliferation inhibitor. The results indicated that tyrosine phosphatase activity, inhibited by orthovanadate, was not involved in the signal transduction pathway of the SGP.
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
S
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-8443
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NASA
pubmed:authorsComplete
Y
pubmed:pagination
40-5
pubmed:dateRevised
2008-2-26
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The use of the tyrosine phosphatase antagonist orthovanadate in the study of a cell proliferation inhibitor.
pubmed:affiliation
Division of Biology, NSCORT, Kansas State University, Manhattan 66506, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't