| pubmed-article:11536535 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11536535 | lifeskim:mentions | umls-concept:C2717875 | lld:lifeskim |
| pubmed-article:11536535 | lifeskim:mentions | umls-concept:C0009226 | lld:lifeskim |
| pubmed-article:11536535 | lifeskim:mentions | umls-concept:C0009235 | lld:lifeskim |
| pubmed-article:11536535 | lifeskim:mentions | umls-concept:C0030342 | lld:lifeskim |
| pubmed-article:11536535 | lifeskim:mentions | umls-concept:C0042890 | lld:lifeskim |
| pubmed-article:11536535 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:11536535 | lifeskim:mentions | umls-concept:C0486616 | lld:lifeskim |
| pubmed-article:11536535 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:11536535 | lifeskim:mentions | umls-concept:C0070039 | lld:lifeskim |
| pubmed-article:11536535 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11536535 | pubmed:dateCreated | 1995-8-8 | lld:pubmed |
| pubmed-article:11536535 | pubmed:abstractText | Pantoic acid can by synthesized in good prebiotic yield from isobutyraldehyde or alpha-ketoisovaleric acid + H2CO + HCN. Isobutyraldehyde is the Strecker precursor to valine and alpha-ketoisovaleric acid is the valine transamination product. Mg2+ and Ca2+ as well as several transition metals are catalysts for the alpha-ketoisovaleric acid reaction. Pantothenic acid is produced from pantoyl lactone (easily formed from pantoic acid) and the relatively high concentrations of beta-alanine that would be formed on drying prebiotic amino acid mixtures. There is no selectivity for this reaction over glycine, alanine, or gamma-amino butyric acid. The components of coenzyme A are discussed in terms of ease of prebiotic formation and stability and are shown to be plausible choices, but many other compounds are possible. The gamma-OH of pantoic acid needs to be capped to prevent decomposition of pantothenic acid. These results suggest that coenzyme A function was important in the earliest metabolic pathways and that the coenzyme A precursor contained most of the components of the present coenzyme. | lld:pubmed |
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| pubmed-article:11536535 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11536535 | pubmed:citationSubset | S | lld:pubmed |
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| pubmed-article:11536535 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11536535 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11536535 | pubmed:issn | 0022-2844 | lld:pubmed |
| pubmed-article:11536535 | pubmed:author | pubmed-author:MillerS LSL | lld:pubmed |
| pubmed-article:11536535 | pubmed:author | pubmed-author:SchlesingerGG | lld:pubmed |
| pubmed-article:11536535 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11536535 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:11536535 | pubmed:owner | NASA | lld:pubmed |
| pubmed-article:11536535 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11536535 | pubmed:pagination | 308-14 | lld:pubmed |
| pubmed-article:11536535 | pubmed:dateRevised | 2007-7-17 | lld:pubmed |
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| pubmed-article:11536535 | pubmed:meshHeading | pubmed-meshheading:11536535... | lld:pubmed |
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| pubmed-article:11536535 | pubmed:meshHeading | pubmed-meshheading:11536535... | lld:pubmed |
| pubmed-article:11536535 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:11536535 | pubmed:articleTitle | Prebiotic syntheses of vitamin coenzymes: II. Pantoic acid, pantothenic acid, and the composition of coenzyme A. | lld:pubmed |
| pubmed-article:11536535 | pubmed:affiliation | Department of Chemistry, University of California, San Diego, La Jolla 92093-0317. | lld:pubmed |
| pubmed-article:11536535 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11536535 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11536535 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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