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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1995-8-8
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pubmed:abstractText |
Pantoic acid can by synthesized in good prebiotic yield from isobutyraldehyde or alpha-ketoisovaleric acid + H2CO + HCN. Isobutyraldehyde is the Strecker precursor to valine and alpha-ketoisovaleric acid is the valine transamination product. Mg2+ and Ca2+ as well as several transition metals are catalysts for the alpha-ketoisovaleric acid reaction. Pantothenic acid is produced from pantoyl lactone (easily formed from pantoic acid) and the relatively high concentrations of beta-alanine that would be formed on drying prebiotic amino acid mixtures. There is no selectivity for this reaction over glycine, alanine, or gamma-amino butyric acid. The components of coenzyme A are discussed in terms of ease of prebiotic formation and stability and are shown to be plausible choices, but many other compounds are possible. The gamma-OH of pantoic acid needs to be capped to prevent decomposition of pantothenic acid. These results suggest that coenzyme A function was important in the earliest metabolic pathways and that the coenzyme A precursor contained most of the components of the present coenzyme.
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pubmed:keyword |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
S
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-Butyrolactone,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Alanine,
http://linkedlifedata.com/resource/pubmed/chemical/Aldehydes,
http://linkedlifedata.com/resource/pubmed/chemical/Coenzyme A,
http://linkedlifedata.com/resource/pubmed/chemical/Coenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxybutyrates,
http://linkedlifedata.com/resource/pubmed/chemical/Keto Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Pantothenic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-ketoisovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/isobutyraldehyde,
http://linkedlifedata.com/resource/pubmed/chemical/pantoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/pantolactone
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-2844
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NASA
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pubmed:authorsComplete |
Y
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pubmed:pagination |
308-14
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pubmed:dateRevised |
2007-7-17
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pubmed:meshHeading |
pubmed-meshheading:11536535-4-Butyrolactone,
pubmed-meshheading:11536535-Adenosine Triphosphate,
pubmed-meshheading:11536535-Alanine,
pubmed-meshheading:11536535-Aldehydes,
pubmed-meshheading:11536535-Biogenesis,
pubmed-meshheading:11536535-Coenzyme A,
pubmed-meshheading:11536535-Coenzymes,
pubmed-meshheading:11536535-Glycine,
pubmed-meshheading:11536535-Hydrogen-Ion Concentration,
pubmed-meshheading:11536535-Hydroxybutyrates,
pubmed-meshheading:11536535-Keto Acids,
pubmed-meshheading:11536535-Pantothenic Acid,
pubmed-meshheading:11536535-Protein Precursors
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pubmed:year |
1993
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pubmed:articleTitle |
Prebiotic syntheses of vitamin coenzymes: II. Pantoic acid, pantothenic acid, and the composition of coenzyme A.
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pubmed:affiliation |
Department of Chemistry, University of California, San Diego, La Jolla 92093-0317.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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