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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-9-5
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pubmed:abstractText |
Adenosine (Ado) and dipyridamole are alternatives to exercise stress for myocardial perfusion imaging. Though generally safe, side effects frequently occur that cause patient discomfort and sometimes lead to premature termination of the study or require aminophylline administration. Recently, a new class of A(2A) Ado receptor agonists was synthesized. ATL193 and ATL146e are 2-propynylcyclohexyl-5'-N-ethylcarboxamido derivatives of Ado. The study goals were to evaluate the potency and selectivity of these new compounds on recombinant canine Ado receptors and to evaluate their hemodynamic properties in dogs to assess their usefulness as vasodilators for myocardial perfusion imaging.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATL 146e,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanecarboxylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Purinergic P1 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Adenosine A2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Adenosine A3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P1,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium Tc 99m Sestamibi
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1181-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11535577-Adenosine,
pubmed-meshheading:11535577-Animals,
pubmed-meshheading:11535577-Binding, Competitive,
pubmed-meshheading:11535577-Blood Pressure,
pubmed-meshheading:11535577-Cell Line,
pubmed-meshheading:11535577-Coronary Disease,
pubmed-meshheading:11535577-Cyclohexanecarboxylic Acids,
pubmed-meshheading:11535577-Dogs,
pubmed-meshheading:11535577-Dose-Response Relationship, Drug,
pubmed-meshheading:11535577-Heart,
pubmed-meshheading:11535577-Hemodynamics,
pubmed-meshheading:11535577-Humans,
pubmed-meshheading:11535577-Infusions, Intravenous,
pubmed-meshheading:11535577-Myocardium,
pubmed-meshheading:11535577-Purinergic P1 Receptor Agonists,
pubmed-meshheading:11535577-Purines,
pubmed-meshheading:11535577-Radioligand Assay,
pubmed-meshheading:11535577-Receptor, Adenosine A2A,
pubmed-meshheading:11535577-Receptor, Adenosine A3,
pubmed-meshheading:11535577-Receptors, Purinergic P1,
pubmed-meshheading:11535577-Recombinant Proteins,
pubmed-meshheading:11535577-Regional Blood Flow,
pubmed-meshheading:11535577-Technetium Tc 99m Sestamibi
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pubmed:year |
2001
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pubmed:articleTitle |
Pharmacological stress myocardial perfusion imaging with the potent and selective A(2A) adenosine receptor agonists ATL193 and ATL146e administered by either intravenous infusion or bolus injection.
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pubmed:affiliation |
Experimental Cardiology Laboratory, Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, USA. dglover@virginia.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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