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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
32
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pubmed:dateCreated |
2001-9-5
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pubmed:abstractText |
To better characterize the cytokine response to measles virus vaccine, we examined the levels of IL-2, IL-4, IL-5, IL-10, IL-12 and gamma-interferon (gamma-IFN) in measles virus-stimulated peripheral blood mononuclear cells from 18 donors before and 2 weeks after vaccination. Donors were grouped as seropositive or seronegative on the basis of measles-specific IgM antibody present at 2 weeks postvaccination. After vaccination, similar levels of upregulation of IL-2 and gamma-IFN mRNA were observed in the two groups. The majority of donors in both groups did not exhibit an increase in measles specific IL-4 or IL-10 mRNA after vaccination. IL-12 mRNA was not induced by measles virus in any of the donors. A statistically significant upregulation of IL-5 mRNA was observed among seropositive (9/13) compared with seronegative (1/5) donors after vaccination (P=0.09, one tailed Fisher's test). The observed measles specific induction of IL-5 mRNA is suggestive of a possible association between IL-5 production and an antibody response to measles virus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Measles Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4896-900
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11535343-Antibodies, Viral,
pubmed-meshheading:11535343-Female,
pubmed-meshheading:11535343-Gene Expression Regulation,
pubmed-meshheading:11535343-Humans,
pubmed-meshheading:11535343-Immunity, Cellular,
pubmed-meshheading:11535343-Immunoglobulin M,
pubmed-meshheading:11535343-Infant,
pubmed-meshheading:11535343-Interferon-gamma,
pubmed-meshheading:11535343-Interleukin-10,
pubmed-meshheading:11535343-Interleukin-12,
pubmed-meshheading:11535343-Interleukin-2,
pubmed-meshheading:11535343-Interleukin-4,
pubmed-meshheading:11535343-Interleukin-5,
pubmed-meshheading:11535343-Interleukins,
pubmed-meshheading:11535343-Leukocytes, Mononuclear,
pubmed-meshheading:11535343-Lymphocyte Activation,
pubmed-meshheading:11535343-Male,
pubmed-meshheading:11535343-Measles Vaccine,
pubmed-meshheading:11535343-Measles virus,
pubmed-meshheading:11535343-Polymerase Chain Reaction,
pubmed-meshheading:11535343-RNA, Messenger,
pubmed-meshheading:11535343-Vaccination
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pubmed:year |
2001
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pubmed:articleTitle |
Induction of cytokine mRNA in peripheral blood mononuclear cells of infants after the first dose of measles vaccine.
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pubmed:affiliation |
Respiratory and Enteric Viruses Branch, Measles Section MS. D11, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. hb11@cdc.gov
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pubmed:publicationType |
Journal Article,
Comparative Study
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