| pubmed-article:11535318 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11535318 | lifeskim:mentions | umls-concept:C0011315 | lld:lifeskim |
| pubmed-article:11535318 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11535318 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:11535318 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:11535318 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:11535318 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:11535318 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:11535318 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:11535318 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11535318 | lifeskim:mentions | umls-concept:C1548795 | lld:lifeskim |
| pubmed-article:11535318 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:11535318 | pubmed:dateCreated | 2001-9-5 | lld:pubmed |
| pubmed-article:11535318 | pubmed:abstractText | Development of a safe and immunogenic tetravalent dengue virus (DV) vaccine has been designated as a priority by the World Health Organization. We characterized the T cell response to DV induced by a candidate live attenuated tetravalent DV vaccine as part of a phase I study. Proliferation and cytotoxic T lymphocyte (CTL) responses to multiple DV serotypes were detected in six of six and four of four subjects studied, respectively. Proliferation responses were higher to DV serotypes 1 and 3 than to serotypes 2 and 4. CTL responses were higher to DV serotypes 2 and 3 than to serotype 1, and included serotype cross-reactive responses. Production of interferon-gamma, but not IL-4, was observed in response to DV stimulation. This candidate vaccine is immunogenic for both CD4+ and CD8+ T lymphocytes. However, T cell responses to the four DV serotypes were not equivalent, suggesting that the vaccine could be further optimized. | lld:pubmed |
| pubmed-article:11535318 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11535318 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535318 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11535318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535318 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11535318 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11535318 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:11535318 | pubmed:author | pubmed-author:EnnisF AFA | lld:pubmed |
| pubmed-article:11535318 | pubmed:author | pubmed-author:WestKK | lld:pubmed |
| pubmed-article:11535318 | pubmed:author | pubmed-author:SaluzzoJ FJF | lld:pubmed |
| pubmed-article:11535318 | pubmed:author | pubmed-author:JanusJJ | lld:pubmed |
| pubmed-article:11535318 | pubmed:author | pubmed-author:RothmanA LAL | lld:pubmed |
| pubmed-article:11535318 | pubmed:author | pubmed-author:Kanesa-thasan... | lld:pubmed |
| pubmed-article:11535318 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11535318 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:11535318 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:11535318 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11535318 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11535318 | pubmed:pagination | 4694-9 | lld:pubmed |
| pubmed-article:11535318 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11535318 | pubmed:meshHeading | pubmed-meshheading:11535318... | lld:pubmed |
| pubmed-article:11535318 | pubmed:meshHeading | pubmed-meshheading:11535318... | lld:pubmed |
| pubmed-article:11535318 | pubmed:meshHeading | pubmed-meshheading:11535318... | lld:pubmed |
| pubmed-article:11535318 | pubmed:meshHeading | pubmed-meshheading:11535318... | lld:pubmed |
| pubmed-article:11535318 | pubmed:meshHeading | pubmed-meshheading:11535318... | lld:pubmed |
| pubmed-article:11535318 | pubmed:meshHeading | pubmed-meshheading:11535318... | lld:pubmed |
| pubmed-article:11535318 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11535318 | pubmed:articleTitle | Induction of T lymphocyte responses to dengue virus by a candidate tetravalent live attenuated dengue virus vaccine. | lld:pubmed |
| pubmed-article:11535318 | pubmed:affiliation | Center for Infectious Disease and Vaccine Research, Rm. S5-326, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. alan.rothman@umassmed.edu | lld:pubmed |
| pubmed-article:11535318 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11535318 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:11535318 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11535318 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:11535318 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11535318 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11535318 | lld:pubmed |
